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载有绿色合成 AGNPS 的水凝胶的合成及创伤愈合性能评价：体外和体内研究。

Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies.

机构信息

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, CS, Italy.

Macrofarm S.R.L, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.

出版信息

Drug Deliv Transl Res. 2022 Aug;12(8):1881-1894. doi: 10.1007/s13346-022-01121-w. Epub 2022 Mar 31.

DOI:10.1007/s13346-022-01121-w
PMID:35359261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9242975/
Abstract

In diabetic patients, the presence of neuropathy, peripheral vascular diseases and ischemia, leads to the formation of foot ulcerations with a higher risk of infection because the normal response to bacterial infection is missing. In the aim to control and treat diabetic foot ulcerations (DFUs), wound dressings that are able to absorb exudate, to prevent infections, and to promote wound healing are needed. For this reason, the aim of the present research was to synthetize a biocompatible hydrogel (called HyDrO-DiAb) composed of carboxymethylcellulose loaded with silver nanoparticles (AgNPs) for the treatment of diabetic foot ulcers. In this study, AgNPs were obtained by a green synthesis and, then, were dissolved in a CMC hydrogel that, after a freeze drying process, becomes a flexible and porous structure. The in vitro and in ex vivo wound healing activity of the obtained HyDrO-DiAb hydrogel was evaluated.

摘要

在糖尿病患者中，神经病变、外周血管疾病和缺血的存在会导致足部溃疡的形成，这些溃疡感染的风险更高，因为正常的细菌感染反应缺失了。为了控制和治疗糖尿病足溃疡（DFUs），需要使用能够吸收渗出物、预防感染和促进伤口愈合的伤口敷料。出于这个原因，本研究的目的是合成一种由羧甲基纤维素负载银纳米粒子（AgNPs）组成的生物相容性水凝胶（称为 HyDrO-DiAb），用于治疗糖尿病足溃疡。在这项研究中，AgNPs 通过绿色合成获得，然后溶解在 CMC 水凝胶中，经过冷冻干燥过程后，形成一种具有柔韧性和多孔结构的水凝胶。评估了所得到的 HyDrO-DiAb 水凝胶的体外和在体伤口愈合活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/7556fd2da38a/13346_2022_1121_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/5a2118b3c6fa/13346_2022_1121_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/c97a91236fff/13346_2022_1121_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/5b532e9d6b6e/13346_2022_1121_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/6d64e903e988/13346_2022_1121_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/03f57275e495/13346_2022_1121_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/1e783081c7ce/13346_2022_1121_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/6ec6808dad85/13346_2022_1121_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/131caaba4740/13346_2022_1121_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/2fa94b6d41ff/13346_2022_1121_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a573/9242975/7556fd2da38a/13346_2022_1121_Fig11_HTML.jpg

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