School of Materials and Physics, China University of Mining and Technology, Xuzhou 221116, China.
School of Materials and Physics, China University of Mining and Technology, Xuzhou 221116, China.
Int J Biol Macromol. 2020 Apr 1;148:501-509. doi: 10.1016/j.ijbiomac.2020.01.156. Epub 2020 Jan 17.
Wound dressings provide barrier protection during wound treatment while providing an environment suitable for wound healing. However, traditional wound dressings have disadvantages, such as easily adhering to wounds, poor barrier effects, and poor haemostasis. Therefore, it is of great significance to design a new wound dressing that does not cause further injury, has good antibacterial effect and promotes wound healing in view of the disadvantages of traditional wound dressings. In this paper, silver nanoparticles (AgNPs) were reduced by in situ reduction with sodium alginate (SA), and construct a silver-loaded PVA/SA/CMCS hydrogel antibacterial wound dressing. The properties of antibacterial hydrogel were evaluated. The results show that SA can successfully reduce AgNPs, and the particle size is small and uniform, which meets the requirements of antibacterial material. The AgNPs are evenly distributed inside the hydrogel and have stable performance. The silver-loaded hydrogel was formed uniform pores inside the material, and had excellent water absorption and water retention, which can absorb a large amount of wound exudate while maintaining a moist wound environment. The antibacterial hydrogel exhibited good mechanical properties, antibacterial activity and biocompatibility. In summary, the silver-loaded hydrogel is an ideal wound dressing.
伤口敷料在伤口治疗过程中提供屏障保护，同时为伤口愈合提供适宜的环境。然而，传统的伤口敷料存在一些缺点，如容易粘在伤口上、屏障效果差、止血效果差等。因此，针对传统伤口敷料的缺点，设计一种不会造成进一步伤害、具有良好抗菌效果和促进伤口愈合的新型伤口敷料具有重要意义。本文采用海藻酸钠（SA）原位还原法制备了载银的 PVA/SA/CMCS 水凝胶抗菌伤口敷料，并对其抗菌性能进行了评价。结果表明，SA 能成功还原 AgNPs，且粒径小且均匀，满足抗菌材料的要求。AgNPs 在水凝胶内均匀分布，性能稳定。载银水凝胶在材料内部形成均匀的孔隙，具有良好的吸水性和保水性，能吸收大量伤口渗出液的同时保持伤口湿润的环境。抗菌水凝胶具有良好的机械性能、抗菌活性和生物相容性。综上所述，载银水凝胶是一种理想的伤口敷料。
