Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Institute of Aging and Age-related Disease Research, Central South University, Changsha, Hunan 410011, China.
Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Institute of Aging and Age-related Disease Research, Central South University, Changsha, Hunan 410011, China.
Ageing Res Rev. 2021 Dec;72:101480. doi: 10.1016/j.arr.2021.101480. Epub 2021 Oct 1.
Vascular aging is a major cause of morbidity and mortality in the elderly population. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), forming the intima and media layers of the vessel wall respectively, are closely associated with the process of vascular aging and vascular aging-related diseases. Numerous studies have revealed the pathophysiologic mechanism through which lncRNA contributes to vascular aging, hence more attention is now paid to the role played by antisense long non-coding RNA (AS-lncRNA) in the pathogenesis of vascular aging. Nonetheless, only a small number of studies focus on the specific mechanism through which AS-lncRNA mediates vascular aging. In this review, we summarize the roles and functions of AS-lncRNA with regards to the development of vascular aging and vascular aging-related disease. We also aim to deepen our understanding of this process and provide alternative therapeutic modalities for vascular aging-related diseases.
血管衰老（Vascular aging）是老年人群发病率和死亡率的主要原因。内皮细胞（Endothelial cells，ECs）和血管平滑肌细胞（Vascular smooth muscle cells，VSMCs）分别构成血管壁的内膜和中膜，它们与血管衰老和与血管衰老相关的疾病的发生过程密切相关。大量研究揭示了长链非编码 RNA（Long non-coding RNA，lncRNA）在血管衰老中的病理生理机制，因此现在更多地关注反义长链非编码 RNA（Antisense long non-coding RNA，AS-lncRNA）在血管衰老发病机制中的作用。然而，只有少数研究关注 AS-lncRNA 介导血管衰老的具体机制。在这篇综述中，我们总结了 AS-lncRNA 在血管衰老和与血管衰老相关疾病发展中的作用和功能。我们还旨在加深对这一过程的理解，并为与血管衰老相关的疾病提供替代治疗方法。
