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病例报告:接种新型冠状病毒肺炎(COVID-19)灭活疫苗后出现抗NF186阳性慢性炎症性脱髓鞘性多发性神经病(CIDP)

Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19).

作者信息

Wen Shirui, Huang Kailing, Zhu Haoyue, Li Peihong, Zhou Luo, Feng Li

机构信息

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

出版信息

Front Neurol. 2022 Mar 14;13:838222. doi: 10.3389/fneur.2022.838222. eCollection 2022.

Abstract

Corona Virus Disease 2019 (COVID-19), the novel coronavirus disease, is now a global pandemic. Vaccination can significantly reduce the mortality rate caused by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). There are currently several effective vaccines that have been introduced. Inactivated COVID-19 vaccine is one of these options and is generally considered safe. Neurofascin (NF) plays an important role in keeping the functionality of the node of Ranvier. We report here a rare case of anti-NF186+ chronic inflammatory demyelinating polyneuropathy (CIDP) in a 23-year-old male patient who was vaccinated with inactivated COVID-19 vaccine prior to the onset. This report adds a new possible rare side effect of a COVID-19 vaccine and provides a case for the clinical effectiveness of rituximab (RTX) in patients with anti-NF186+ CIDP.

摘要

2019冠状病毒病(COVID-19),即新型冠状病毒病,现已成为全球大流行疾病。接种疫苗可显著降低由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的死亡率。目前已有几种有效的疫苗投入使用。灭活COVID-19疫苗是其中一种选择,通常被认为是安全的。神经束蛋白(NF)在维持郎飞结的功能方面发挥着重要作用。我们在此报告一例罕见病例,一名23岁男性患者在接种灭活COVID-19疫苗后发病,出现抗NF186 +慢性炎症性脱髓鞘性多发性神经病(CIDP)。本报告增加了COVID-19疫苗一种新的可能的罕见副作用,并提供了利妥昔单抗(RTX)治疗抗NF186 + CIDP患者临床有效性的病例。

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