Frecker M, Fraser F C
Division of Community Medicine, Memorial University, St. John's, Newfoundland, Canada.
Teratology. 1987 Dec;36(3):355-61. doi: 10.1002/tera.1420360312.
A 9-year survey of neural tube defects in Newfoundland showed (1) evidence for secular variation, with a peak in 1980, but no general downward trend as seen in some other populations; (2) significant geographic variation which did not correlate with hardness or nitrate content of the lake water; (3) a tendency for the proportion of females among anencephalic births to increase with increasing frequency of anencephaly among geographic regions. This supports previous evidence for a female-specific contribution to the causes of increased liability to neural tube defect.
对纽芬兰神经管缺陷进行的一项为期9年的调查显示：（1）有长期变化的证据，1980年出现峰值，但未呈现出其他一些人群中所见的总体下降趋势；（2）存在显著的地理差异，且与湖水的硬度或硝酸盐含量无关；（3）无脑儿出生中女性所占比例有随着地理区域无脑儿发生率增加而上升的趋势。这支持了先前关于女性在神经管缺陷易感性增加原因中具有特定作用的证据。
