Doctoral Programs, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Department of Physiotherapy, Faculty of Nursing, Hasanuddin University, Makassar, Indonesia.
Biomed Res Int. 2022 Mar 22;2022:9887985. doi: 10.1155/2022/9887985. eCollection 2022.
Exercise in the form of physical activity can provide neuroprotective benefits. The purpose of this study is to determine the effect of the task balance training program (TBT program) on the glial cell-derived neurotrophic factor levels, cognitive function, and postural balance in old people. The population of this study was the old people members of the Batara Hati Mulia Gowa Foundation who were willing to participate in the study ( = 66). The sample of this study was obtained through a random sampling technique to determine the treatment ( = 32) and control ( = 34) groups. Before and after implementing the TBT program, glial cell-derived neurotrophic factor (GDNF) level measurement and cognitive function and postural balance assessment were performed. Cognitive function was measured by using Montreal cognitive assessment (MoCA). Postural balance was measured in two ways by using the timed up and go (TUG) test and Tinetti performance-oriented mobility assessment (POMA). The treatment group showed significantly greater changes than the control group in GDNF levels (2.24 (±0.63) vs. 1.24 (±0.43), = 0.001), cognitive function (24.66 (±3.42) vs. 19.18 (±2.67), = 0.001), and postural balance (TUG [14.00 (±4.04) vs. 18.68 (±3.98)]; POMA [26.53 (±1.74) vs. 23.47 (±3.06)], = 0.001) after training. The treatment group also showed a significant relationship between GDNF levels and cognitive function ( = 0.840, = 0.001) and postural balance (TUG [ = 0.814, = 0.001]; POMA [ = 0.630, = 0.001]). The TBT program affects the levels of GDNF in old people. The TBT program involves cognitive function improvement and affects postural balance changes in old people.
锻炼形式的身体活动可以提供神经保护益处。本研究的目的是确定任务平衡训练计划（TBT 计划）对老年人神经胶质细胞源性神经营养因子水平、认知功能和姿势平衡的影响。本研究的人群是愿意参加研究的巴塔拉哈蒂穆利亚高哇基金会的老年人（n=66）。本研究的样本通过随机抽样技术获得，以确定治疗（n=32）和对照组（n=34）。在实施 TBT 计划之前和之后，测量神经胶质细胞源性神经营养因子（GDNF）水平，并评估认知功能和姿势平衡。认知功能通过蒙特利尔认知评估（MoCA）进行测量。姿势平衡通过计时起身和行走（TUG）测试和 Tinetti 面向性能的移动评估（POMA）两种方式进行测量。治疗组在 GDNF 水平（2.24（±0.63）vs. 1.24（±0.43），=0.001）、认知功能（24.66（±3.42）vs. 19.18（±2.67），=0.001）和姿势平衡（TUG [14.00（±4.04）vs. 18.68（±3.98）]；POMA [26.53（±1.74）vs. 23.47（±3.06）]，=0.001）方面的变化明显大于对照组。在训练后，治疗组的 GDNF 水平与认知功能（=0.840，=0.001）和姿势平衡（TUG [=0.814，=0.001]；POMA [=0.630，=0.001]）之间也存在显著关系。TBT 计划影响老年人的 GDNF 水平。TBT 计划涉及认知功能的改善，并影响老年人姿势平衡的变化。
