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九里香叶提取物介导的氧化锌纳米颗粒的体外抗糖尿病、抗氧化、抗菌和细胞毒性活性。

In vitro antidiabetic, antioxidant, antimicrobial, and cytotoxic activity of Murraya koenigii leaf extract intercedes ZnO nanoparticles.

作者信息

Sharma Avinash, Nagraik Rupak, Venkidasamy Baskar, Khan Azhar, Dulta Kanika, Kumar Chauhan Pankaj, Kumar Deepak, Shin Dong-Soo

机构信息

Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, India.

Department of Biotechnology, Sri Shakthi Institute of Engineering and Technology, Coimbatore, Tamil Nadu, India.

出版信息

Luminescence. 2023 Jul;38(7):1139-1148. doi: 10.1002/bio.4244. Epub 2022 Apr 17.

Abstract

Nanotechnology is an emerging field with tremendous potential and usage of medicinal plants and green preparation of nanoparticles (NPs) is one of the widely explored areas. These have been shown to be effective against different biological activities such as diabetes mellitus, cancer, antioxidant, antimicrobial, etc. The current studies focus on the green synthesis of zinc NPs (ZnO NPs) from aqueous leaf extract of Murraya koenigii (MK). The synthesized Murraya koeingii zinc oxide NPs (MK ZnO NPs) were characterized using UV-visible spectroscopy, dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy-dispersive spectrum (EDS) and cyclic voltammetry (CV). The synthesized MK ZnO NPs were evaluated for their in vitro antidiabetic, antioxidant, antimicrobial, and cytotoxic activity. They demonstrated significant antidiabetic and cytotoxic activity, as well as moderate free-radical scavenging and antibacterial activity.

摘要

纳米技术是一个具有巨大潜力的新兴领域,药用植物的利用和纳米颗粒(NPs)的绿色制备是广泛探索的领域之一。这些已被证明对不同的生物活性有效,如糖尿病、癌症、抗氧化、抗菌等。目前的研究集中在从九里香(MK)的水叶提取物中绿色合成锌纳米颗粒(ZnO NPs)。使用紫外可见光谱、动态光散射(DLS)、傅里叶变换红外(FTIR)光谱、场发射扫描电子显微镜(FESEM)、能量色散光谱(EDS)和循环伏安法(CV)对合成的九里香氧化锌纳米颗粒(MK ZnO NPs)进行了表征。对合成的MK ZnO NPs的体外抗糖尿病、抗氧化、抗菌和细胞毒性活性进行了评估。它们表现出显著的抗糖尿病和细胞毒性活性,以及适度的自由基清除和抗菌活性。

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