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海洋鱼类来源的生物活性化合物对癌症的影响。

The Impact of Bioactive Compounds Derived from Marine Fish on Cancer.

机构信息

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Chidambaram-608 002, Tamil Nadu, India.

出版信息

Anticancer Agents Med Chem. 2022 Aug 4;22(15):2757-2765. doi: 10.2174/1871520622666220330142442.

Abstract

Cancer persists as the world's leading cause of mortality, thereby making it a compelling condition to research and potentially develop prevention options. Anticancer therapies such as chemotherapy, surgery and radiation therapy are becoming highly futile and tend to have achieved a clinical deficit due to massive side effects, toxicities, and limited specificity. Anticancer agents from natural sources, such as aquatic fishes, terrestrial mammals, animal venoms, and amphibians, have mainly been focused on in recent researches. Edible marine fishes contain high contents of fatty acids, vitamins, and proteins, also having bioactive compounds. Fish derivatives naturally have the potential to target cancer cells while being less hazardous to normal tissues, making them a better choice for cancer prevention and therapy. In this review, we mainly focused on the bioactive compounds identified in marine fishes which have significant biological properties including anticancer effects, also discuss the mechanism of action.

摘要

癌症仍然是世界上主要的死亡原因,因此对其进行研究并开发潜在的预防方法是非常必要的。癌症治疗方法,如化疗、手术和放射疗法,由于其巨大的副作用、毒性和有限的特异性,变得越来越没有效果,而且往往已经达到了临床的不足。最近的研究主要集中在来自天然来源的抗癌药物上,如水生鱼类、陆地哺乳动物、动物毒液和两栖动物。食用海洋鱼类含有丰富的脂肪酸、维生素和蛋白质,也含有生物活性化合物。鱼类衍生物自然具有靶向癌细胞的潜力,而对正常组织的危害较小,因此它们是癌症预防和治疗的更好选择。在这篇综述中,我们主要集中在海洋鱼类中发现的具有显著生物学特性的生物活性化合物上,包括抗癌作用,并讨论其作用机制。

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