Department of Orthopedics and Traumatology, Health Sciences University, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
Eur Rev Med Pharmacol Sci. 2022 Mar;26(6):1945-1951. doi: 10.26355/eurrev_202203_28342.
This study aimed at investigating the laboratory parameters related to the pathogenesis of bone loss, including bone mineral density (BMD), neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) in children with thyroid disease and healthy controls.
Children and adolescents with hypothyroidism (n=63) and hyperthyroidism (n=30) as well as 32 age- and sex-matched healthy controls were included in the study. Auxological data, BMD, hemogram parameters, the levels of thyroid hormone, thyroid stimulating hormone (TSH), thyroid autoantibodies, parathyroid hormone, 25-hydroxy vitamin D, alkaline phosphatase, calcium, and phosphorus were analyzed.
The mean age of the patients was 12.12±2.7 years (range: 8-17). BMD Z-scores were within the normal range in all the patients and healthy controls. The BMD Z-scores were significantly higher in patients with hyperthyroidism than those in the control group and in patients with hypothyroidism. No significant difference was observed between the control and hypothyroid groups in terms of the BMD Z-scores. A correlation was observed between the BMD Z-scores and NLR, MLR, PLR, and free T4 levels. In patients with hypothyroidism, the BMD Z-scores were significantly positively correlated with the NLR, MLR, PLR, and the TSH level. In the control group, there was a moderate positive correlation between the BMD Z-scores and NLR. In the hyperthyroid group, there were no significant correlations between the BMD Z-scores and other variables.
The study data suggest that in children and adolescents with thyroid disease, the relationship between the BMD Z-scores and NLR, MLR, and PLR at the initial diagnosis in the hypothyroidism group was different from that in their healthy peers.
本研究旨在探讨与骨丢失发病机制相关的实验室参数，包括甲状腺疾病患儿和健康对照者的骨密度（BMD）、中性粒细胞-淋巴细胞比值（NLR）、单核细胞-淋巴细胞比值（MLR）和血小板-淋巴细胞比值（PLR）。
纳入 63 例甲状腺功能减退症患儿和 30 例甲状腺功能亢进症患儿以及 32 名年龄和性别匹配的健康对照者。分析了人体测量数据、BMD、血常规参数、甲状腺激素、促甲状腺激素（TSH）、甲状腺自身抗体、甲状旁腺激素、25-羟维生素 D、碱性磷酸酶、钙和磷的水平。
患者的平均年龄为 12.12±2.7 岁（范围：8-17 岁）。所有患者和健康对照者的 BMD Z 评分均在正常范围内。与对照组和甲状腺功能减退症患者相比，甲状腺功能亢进症患者的 BMD Z 评分明显更高。对照组和甲状腺功能减退症患者的 BMD Z 评分无显著差异。BMD Z 评分与 NLR、MLR、PLR 和游离 T4 水平呈正相关。在甲状腺功能减退症患者中，BMD Z 评分与 NLR、MLR、PLR 和 TSH 水平呈显著正相关。在对照组中，BMD Z 评分与 NLR 呈中度正相关。在甲状腺功能亢进症患者中，BMD Z 评分与其他变量无显著相关性。
研究数据表明，在甲状腺疾病患儿中，甲状腺功能减退症组患儿初诊时 BMD Z 评分与 NLR、MLR 和 PLR 的关系与健康同龄人不同。
