Mohammadshahi Jafar, Ghobadi Hassan, Shargi Afshan, Moradkhani Hossein, Rezaei Hamed, Kazemy Mahur, Aslani Mohammad Reza
Department of Infectious Diseases and Tropical Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Mediators Inflamm. 2024 Dec 28;2024:5720709. doi: 10.1155/mi/5720709. eCollection 2024.
The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), derived neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte and platelet ratio (N/LP ratio), aggregate index of systemic inflammation (AISI), systemic inflammation response index (SIRI), and systemic inflammation index (SII) have emerged as noteworthy determinants in evaluating the severity and mortality prognosis of inflammatory diseases. In order to predict mortality rate, this study aimed to assess the impact of systemic inflammatory markers on both men and women who were admitted to the hospital due to SARS-CoV-2 infection. The laboratory parameters of the 2007 COVID-19 patients were analyzed in a retrospective study (men = 1145 and women = 862). Receiver operating characteristic (ROC) analysis was used to determine the capability of inflammatory markers to differentiate the severity of COVID-19, while survival probability was determined using Kaplan-Meier curves, with the endpoint being death. To prevent any linear bias, the inflammatory indices were assessed separately using univariate analysis for Charlson comorbidity index (CCI), and adjustments were made for confounding factors if < 0.2. Adjusted-NLR, adjusted-MLR, N/LP ratio, adjusted-dNLR, adjusted-AISI, adjusted-SII, and adjusted-SIRI exhibited remarkably higher values in patients who did not survive as compared to those who did. The multivariate Cox regression models demonstrated significant association between survival and N/LP ratio (HR = 1.564, 95% CI = 1.161 to 2.107, < 0.01) in men and N/LP ratio (HR = 1.745, 95% CI = 1.230 to 2.477, < 0.01) and adjusted-SII (HR = 6.855, 95% CI = 1.454 to 32.321, < 0.05) in women. A reliable predictor in the current study of men and women with COVID-19 was N/LP ratio.
中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）、血小板与淋巴细胞比值（PLR）、衍生中性粒细胞与淋巴细胞比值（dNLR）、中性粒细胞与淋巴细胞及血小板比值（N/LP比值）、全身炎症聚集指数（AISI）、全身炎症反应指数（SIRI）和全身炎症指数（SII）已成为评估炎症性疾病严重程度和死亡预后的重要决定因素。为了预测死亡率，本研究旨在评估全身炎症标志物对因SARS-CoV-2感染入院的男性和女性的影响。在一项回顾性研究中分析了2007例COVID-19患者的实验室参数（男性 = 1145例，女性 = 862例）。采用受试者工作特征（ROC）分析来确定炎症标志物区分COVID-19严重程度的能力，同时使用Kaplan-Meier曲线确定生存概率，终点为死亡。为防止任何线性偏差，使用Charlson合并症指数（CCI）的单因素分析分别评估炎症指标，若P<0.2，则对混杂因素进行调整。与存活患者相比，未存活患者的调整后NLR、调整后MLR、N/LP比值、调整后dNLR、调整后AISI、调整后SII和调整后SIRI的值显著更高。多因素Cox回归模型显示，男性的生存与N/LP比值（HR = 1.564，95%CI = 1.161至2.107，P<0.01）以及女性的N/LP比值（HR = 1.745，95%CI = 1.230至2.477，P<0.01）和调整后SII（HR = 6.855，95%CI = 1.454至32.321，P<0.05）之间存在显著关联。在当前对COVID-19男性和女性的研究中，一个可靠的预测指标是N/LP比值。
