Franquet Tomás, Franks Teri J, Lee Kyung Soo, Marchiori Edson, Mazzini Sandra, Giménez Ana, Johkoh Takeshi, Cho Junhun, Galvin Jeffrey R
From the Department of Diagnostic Radiology, Hospital de Sant Pau, Universidad Autónoma de Barcelona, C/ Sant Quintí 89, 08041, Barcelona, Spain (T.F., S.M., A.G.); Department of Pulmonary and Mediastinal Pathology, Department of Defense, the Joint Pathology Center, Silver Spring, Md, and Department of Chest Imaging, American Institute for Radiologic Pathology, Silver Spring, Md (T.J.F.); Department of Radiology, Samsung ChangWon Hospital, Sungkyunkwan University School of Medicine (SKKU-SOM), ChangWon, Gyeongsangnam-Do, Korea (K.S.L.); Department of Radiology, Hospital Universitário Clementino Fraga Filho-Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil (E.M.); Department of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine (SKKU-SOM), Seoul, Korea (J.C.); and Departments of Diagnostic Radiology and Internal Medicine, University of Maryland School of Medicine, Baltimore, Md (J.R.G.).
Radiographics. 2022 May-Jun;42(3):644-660. doi: 10.1148/rg.210157. Epub 2022 Apr 1.
Approximately 1.4 million virus-induced cancers occur annually, representing roughly 10% of the cancer burden worldwide. Seven oncogenic DNA and RNA viruses (ie, oncoviruses) are implicated in approximately 12%-25% of all human cancers owing to a variety of mechanisms as uncommon consequences of the normal viral life cycle. These seven well-recognized human oncoviruses are Epstein-Barr virus (EBV), human T-lymphotropic virus 1, hepatitis B virus, hepatitis C virus, HIV, human papilloma virus (HPV), and human herpesvirus 8 (HHV-8). Several viruses-namely, EBV, HPV, and Kaposi sarcoma herpesvirus or HHV-8-are increasingly being recognized as being related to HIV and/or AIDS, the growing number of transplant cases, and the use of immunosuppressive therapies. Infectious and inflammatory processes, and the accompanying lymphadenopathy, are great mimickers of human oncovirus-related tumors. Although it is often difficult to differentiate these entities, the associated clinical setting and radiologic findings may provide clues for an accurate diagnosis and appropriate management. Malignant lymphoid lesions are best evaluated with multidetector chest CT. The radiologic findings of these lesions are often nonspecific and are best interpreted in correlation with clinical data and histopathologic findings. RSNA, 2022.
每年约有140万例病毒诱导的癌症发生，约占全球癌症负担的10%。七种致癌DNA和RNA病毒（即肿瘤病毒）由于各种机制，作为正常病毒生命周期的罕见后果，与约12%-25%的人类癌症有关。这七种公认的人类肿瘤病毒是爱泼斯坦-巴尔病毒（EBV）、人类嗜T淋巴细胞病毒1型、乙型肝炎病毒、丙型肝炎病毒、HIV、人乳头瘤病毒（HPV）和人类疱疹病毒8型（HHV-8）。几种病毒，即EBV、HPV和卡波西肉瘤疱疹病毒或HHV-8，越来越被认为与HIV和/或艾滋病、移植病例数量的增加以及免疫抑制疗法的使用有关。感染性和炎症过程以及伴随的淋巴结病，很容易与人类肿瘤病毒相关肿瘤相混淆。尽管通常很难区分这些实体，但相关的临床情况和影像学表现可能为准确诊断和适当治疗提供线索。恶性淋巴病变最好用多排螺旋胸部CT进行评估。这些病变的影像学表现通常不具有特异性，最好结合临床数据和组织病理学发现进行解读。RSNA，2022年。
