Warowicka Alicja, Nawrot Robert, Broniarczyk Justyna, Węglewska Martyna, Goździcka-Józefiak Anna
Zakład Fizjologii i Biologii Rozwoju Zwierząt, Uniwersytet im.Adama Mickiewicza w Poznaniu.
Pracownia Wirusologii Molekularnej, Uniwersytet im.Adama Mickiewicza w Poznaniu.
Postepy Biochem. 2021 Jan 5;66(4):336-355. doi: 10.18388/pb.2020_360. Print 2020 Dec 31.
Oncogenic viruses (oncoviruses) are implicated in approximately 12% of all human cancers. Currently, the viruses known to cause human cancer are: Hepatitis B and C viruses (HBV and HCV), Human Papillomaviruses (HPV), Merkel Cell Polyomavirus (MCV), Human Herpesvirus-8 (HHV-8), Epstein-Barr Virus (EBV) and Human T-cell lymphotropic virus-1 (HTLV-1). However, oncoviruses are not complete carcinogens, need additional factors andisplay different roles in transformation. Oncoviruses can directly disrupt important regulatory cell genes by inserting virus genom into the DNA of the host cell. They also contain their own genes that damage the regulation of the cell. Some viruses have v-onc that cause disregulation of cellular processes and can lead to cancerous growth.
致癌病毒与大约12%的人类癌症有关。目前，已知可导致人类癌症的病毒有：乙型和丙型肝炎病毒（HBV和HCV）、人乳头瘤病毒（HPV）、默克尔细胞多瘤病毒（MCV）、人类疱疹病毒8型（HHV-8）、爱泼斯坦-巴尔病毒（EBV）和人类嗜T细胞病毒1型（HTLV-1）。然而，致癌病毒并非完全致癌物，需要其他因素，并且在细胞转化过程中发挥不同作用。致癌病毒可通过将病毒基因组插入宿主细胞的DNA中，直接破坏重要的细胞调节基因。它们还含有自身的基因，这些基因会损害细胞的调节功能。一些病毒具有v-onc，可导致细胞过程失调，并可能导致癌性生长。
