Browne J L, Hauge K J
Drug Intell Clin Pharm. 1986 Nov;20(11):837-41. doi: 10.1177/106002808602001102.
A cumulative review of case reports in the literature describing withdrawal reactions secondary to alprazolam is presented. In four of eight reports, the primary withdrawal manifestations were grand mal seizures. One case was characterized by painful myoclonus. In the remaining three cases, the major complications consisted of rebound anxiety with psychotic features. Despite tapering of the daily dosage according to manufacturer guidelines, a withdrawal syndrome was precipitated in three of the cases. As a result of alprazolam's atypical pharmacodynamic profile, the issue is raised as to whether alprazolam is pharmacologically cross-tolerant with other benzodiazepines.
本文对文献中描述的阿普唑仑继发戒断反应的病例报告进行了累积回顾。在八份报告中的四份中，主要的戒断表现为癫痫大发作。有一例以疼痛性肌阵挛为特征。在其余三例中，主要并发症包括伴有精神病性特征的反弹性焦虑。尽管按照制造商指南逐渐减少每日剂量，但仍有三例引发了戒断综合征。由于阿普唑仑具有非典型的药效学特征，因此引发了关于阿普唑仑在药理学上是否与其他苯二氮䓬类药物有交叉耐受性的问题。
