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牛奶蛋白过敏的营养目标:全面综述。

Nutritional Targets in Cow's Milk Protein Allergy: A Comprehensive Review.

机构信息

Department of Nutrition and Dietetics, Gazi University, Emek, Ankara, 06490, Turkey.

出版信息

Curr Nutr Rep. 2022 Jun;11(2):329-336. doi: 10.1007/s13668-022-00408-1. Epub 2022 Apr 2.

DOI:10.1007/s13668-022-00408-1
PMID:35366189
Abstract

PURPOSE OF REVIEW

Cow's milk protein allergy (CMPA) is known as the most common food allergy in the first year of life. For this purpose, in our review, the regulation of maternal and infant nutrition, and the risks and the issues to be considered in terms of nutrition are discussed from the perspective of a dietitian.

RECENT FINDINGS

Therefore, understanding the epidemiology, symptoms, diagnostic criteria, and appropriate treatment of cow's milk protein allergy is crucial for the multidisciplinary team of physicians, dietitians, and nurses working in the clinic. It has been reported that tolerance develops in approximately 50% of infants affected by cow's milk protein in the first year of life. Although CMPA is generally thought to clear up between 1 and 2 years of age, there is insufficient evidence to determine an optimal time to reintroduce cow's milk protein to the diet. Because the elimination diet recommended in the treatment of children with CMPA, adequate protein and calcium intake of the mother and/or baby in the diet should be evaluated. Studies focusing on metabolic bone turnover in children with food allergies are limited. In general, low calcium intake is associated with reduced bone formation in children with CMPA. Therefore, bone health should be focused on and appropriate strategies should be developed in children with CMPA. Unnecessary elimination of milk and its products, which are an important part of nutrition, should be prevented and nutrient deficiencies and growth status should be monitored by dietitians especially working in the field of pediatric nutrition.

摘要

目的综述

牛乳蛋白过敏(CMPA)是婴儿期最常见的食物过敏。为此,本综述从营养师的角度,讨论了母婴营养的调控以及在营养方面需要考虑的风险和问题。

最新发现

因此,了解牛乳蛋白过敏的流行病学、症状、诊断标准和适当的治疗方法,对于临床工作中的医师、营养师和护士多学科团队至关重要。据报道,约有 50%的牛乳蛋白过敏婴儿在生命的第一年可发展为耐受。虽然 CMPA 通常认为在 1 至 2 岁之间消退,但尚无足够证据确定重新引入牛乳蛋白到饮食中的最佳时间。由于 CMPA 患儿治疗中推荐的饮食排除疗法,应评估母亲和/或婴儿饮食中蛋白质和钙的充足摄入。关注食物过敏儿童代谢性骨转换的研究有限。一般来说,低钙摄入与 CMPA 患儿骨形成减少有关。因此,应关注骨健康,并为 CMPA 患儿制定适当的策略。营养师特别是在儿科营养领域工作的营养师应预防不必要的牛乳及其制品的排除,因为它们是营养的重要组成部分,并应监测营养缺乏和生长状况。

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Cow's milk protein allergy: A comprehensive review of epidemiology, pathogenesis, clinical manifestations, diagnostics, and management strategies.牛奶蛋白过敏:流行病学、发病机制、临床表现、诊断及管理策略的全面综述
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本文引用的文献

1
Guidelines on Diagnosis and Management of Cow's Milk Protein Allergy.牛奶蛋白过敏诊断与管理指南。
Indian Pediatr. 2020 Aug 15;57(8):723-729.
2
Association of Cow's Milk Protein Allergy Prevalence With Socioeconomic Status in a Cohort of Chilean Infants.牛奶蛋白过敏患病率与智利队列中婴儿社会经济地位的关系。
J Pediatr Gastroenterol Nutr. 2020 Sep;71(3):e80-e83. doi: 10.1097/MPG.0000000000002787.
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Diagnosis and management of Non-IgE gastrointestinal allergies in breastfed infants-An EAACI Position Paper.母乳喂养婴儿非IgE介导的胃肠道过敏的诊断与管理——欧洲变态反应和临床免疫学会立场文件
Severe upper gastrointestinal hemorrhage due to milk protein allergy: A case report.
牛奶蛋白过敏导致的严重上消化道出血:一例报告。
World J Clin Cases. 2025 May 16;13(14):104039. doi: 10.12998/wjcc.v13.i14.104039.
4
Growth in healthy infants with cow's milk protein allergy fed extensively hydrolyzed or amino acid-based formulas.以深度水解配方奶粉或氨基酸配方奶粉喂养的牛奶蛋白过敏健康婴儿的生长情况。
BMC Nutr. 2024 Jul 19;10(1):101. doi: 10.1186/s40795-024-00901-6.
5
Nutritional Strategies for the Prevention and Management of Cow's Milk Allergy in the Pediatric Age.婴幼儿牛奶过敏的预防和管理的营养策略。
Nutrients. 2023 Jul 26;15(15):3328. doi: 10.3390/nu15153328.
6
The use of amino acid formulas in pediatric patients with allergy to cow's milk proteins: Recommendations from a group of experts.牛奶蛋白过敏儿科患者中氨基酸配方奶粉的使用:一组专家的建议。
Front Pediatr. 2023 Mar 22;11:1110380. doi: 10.3389/fped.2023.1110380. eCollection 2023.
Allergy. 2020 Jan;75(1):14-32. doi: 10.1111/all.13947. Epub 2019 Aug 27.
4
Children with cow's milk allergy following an elimination diet had normal growth but relatively low plasma leptin at age two.经排除饮食法治疗后对牛奶过敏的儿童在两岁时生长正常,但血浆瘦素相对较低。
Acta Paediatr. 2018 Jul;107(7):1247-1252. doi: 10.1111/apa.14283. Epub 2018 Mar 24.
5
Mineral Intake and Status of Cow's Milk Allergic Infants Consuming an Amino Acid-based Formula.食用氨基酸配方奶粉的牛奶过敏婴儿的矿物质摄入量和状况
J Pediatr Gastroenterol Nutr. 2017 Sep;65(3):346-349. doi: 10.1097/MPG.0000000000001655.
6
Evidence that eating baked egg or milk influences egg or milk allergy resolution: a systematic review.食用烘焙鸡蛋或牛奶对鸡蛋或牛奶过敏缓解影响的证据:一项系统评价。
Clin Exp Allergy. 2017 Jun;47(6):829-837. doi: 10.1111/cea.12940. Epub 2017 May 17.
7
Consensus statement on diagnosis, treatment and follow-up of cow's milk protein allergy among infants and children in Turkey.土耳其婴幼儿牛奶蛋白过敏诊断、治疗及随访的共识声明
Turk J Pediatr. 2016;58(1):1-11. doi: 10.24953/turkjped.2016.01.001.
8
Iodine Status and Growth In 0-2-Year-Old Infants With Cow's Milk Protein Allergy.牛奶蛋白过敏的0至2岁婴幼儿的碘营养状况与生长情况
J Pediatr Gastroenterol Nutr. 2017 May;64(5):806-811. doi: 10.1097/MPG.0000000000001434.
9
Cows' milk exclusion diet during infancy: Is there a long-term effect on children's eating behaviour and food preferences?婴儿期牛奶排除饮食:对儿童饮食行为和食物偏好有长期影响吗?
Pediatr Allergy Immunol. 2016 Mar;27(2):141-6. doi: 10.1111/pai.12513. Epub 2016 Jan 21.
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Calcium requirements from dairy foods in France can be met at low energy and monetary cost.在法国,从乳制品中获取的钙需求可以以较低的能量和金钱成本得到满足。
Br J Nutr. 2015 Dec 14;114(11):1920-8. doi: 10.1017/S0007114515003669. Epub 2015 Oct 9.