Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Diabetes Metab Syndr. 2022 Apr;16(4):102472. doi: 10.1016/j.dsx.2022.102472. Epub 2022 Mar 26.
Evaluating the impact of Ramadan fasting on Ambulatory Glucose Profile (AGP) among Patients with Type 1 Diabetes (T1D) using Flash Glucose Monitoring (FGM) System.
The present study is a comparative study, performed using 87 patients with T1D, whose health status permitted them to fast, based on the risk stratification adopted by Diabetes and Ramadan (DAR Guidelines). Besides the demographic data, other data connected with the glycemic profile such as the mean Time in Range (TIR), mean Time Above Range (TAR), mean Time Below Range (TBR), mean glucose level, hemoglobin A1c (HbA1c), Glucose Variability (GV), and Glucose Monitoring Indicator (GMI %), were recorded at three specific periods, namely, pre- (prior to), during and post Ramadan.
The mean age of the study population was 21.3 ± 8.2 years, and 52.9% of this population was female. Compared to the pre-Ramadan data, no significant alterations (p > 0.05) were noted in terms of the low glucose events, percentage of glucose level below 70 mg/dL, the average duration of hypoglycemic events, and percentage of glucose level below 54 mg/dL, from the values observed during and post-Ramadan. In comparison with the pre-Ramadan data, no significant changes appeared (p > 0.05) concerning the GV, average glucose, GMI, percentage within target, TAR (181-250 mg/dL), and percentage >250 mg/dL), for the periods during and post-Ramadan, except scanning of FreeStyle Libre (p = 0.042) during Ramadan month compared to pre-Ramadan.
Fasting during Ramadan was achievable in patients with T1D who received adequate counseling and support.
使用即时动态血糖监测系统（FGM）评估斋月禁食对 1 型糖尿病（T1D）患者动态血糖谱（AGP）的影响。
本研究是一项比较研究，共纳入 87 名符合条件的 T1D 患者，这些患者在基于糖尿病与斋月（DAR 指南）的风险分层标准后，健康状况允许他们进行禁食。除了人口统计学数据外，还记录了与血糖谱相关的其他数据，如平均血糖达标时间（TIR）、平均血糖高于目标范围时间（TAR）、平均血糖低于目标范围时间（TBR）、平均血糖水平、糖化血红蛋白（HbA1c）、血糖变异性（GV）和血糖监测指标（GMI）%，并在三个特定时期进行记录，即斋月前（Ramadan pre）、斋月期间和斋月后。
研究人群的平均年龄为 21.3±8.2 岁，其中 52.9%为女性。与斋月前的数据相比，在低血糖事件、血糖水平低于 70mg/dL 的比例、低血糖事件的平均持续时间以及血糖水平低于 54mg/dL 的比例方面，在斋月期间和斋月后没有观察到显著变化（p>0.05）。与斋月前的数据相比，在 GV、平均血糖、GMI、目标范围内的百分比、TAR（181-250mg/dL）和血糖水平高于 250mg/dL 的百分比方面，在斋月期间和斋月后没有出现显著变化（p>0.05），除了在斋月期间使用 FreeStyle Libre 扫描的变化外（p=0.042）。
在接受充分咨询和支持的情况下，T1D 患者可以在斋月期间进行禁食。
