Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Department of Continuous Quality Improvement and Patient Safety, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Curr Diabetes Rev. 2024;20(9):e040124225257. doi: 10.2174/0115733998276061231117101716.
To examine the influence of school life in children and adolescents with type 1 diabetes (T1D) by comparing the glycemic control and Ambulatory Glucose Profile (AGP) between the holidays and schooldays.
This is a retrospective study conducted on 147 patients with T1D (14-19 years) who used an intermittently scanned Continuous Glucose Monitoring (isCGM) system to self-test their glucose levels during the periods of school time and holiday time. A record was maintained of the Continuous Glucose Monitoring (CGM) metrics i.e., Glucose Variability (GV) (%), mean Time in Range (TIR), Time above Range (TAR), Time below Range (TBR), and average time period of the hypoglycemic events during schooldays and the holidays.
The study revealed differences between the recorded values during the holidays and schooldays, in % in target 70-180 mg/dL (38.2 vs. 49.5; p = 0.039), mean glucose (194 vs. 185; p = 0.048), frequency of low glucose events (9.2 vs. 5.1; p = 0.036), mean duration of low glucose levels (117 vs. 65; p = 0.021), % TBR below 70 mg/dL (2.9 vs. 1.45; p = 0.023), % TBR below 54 mg/dL (1.1 vs. 0.51; p = 0.031), TAR 181-250 mg/dL (21.1 vs. 16.5; p = 0.037) and TAR >250 mg/dL (8.9 vs. 6.5; p = 0.043). On comparing the HbA1c levels of the study population recorded during the holidays (8.34%) with those recorded during the schooldays (8.13%), the HbA1c values during the school days were observed to be lower; however, no significant changes were noted in the HbA1c level between the holidays and schooldays. Concerning the FreeStyle Libre (FSL) scanning, the frequency during the holidays (n = 6.2) was significantly lower than during the schooldays (n = 9.5) (p = 0.042).
From the findings, it appears that children with T1D have good diabetes control during schooldays rather than during the holidays. To improve their glucose control during the holidays, these patients may also benefit from receiving greater attention and guidance.
通过比较 14-19 岁 1 型糖尿病（T1D）患儿在假期和上学日的血糖控制和动态血糖谱（AGP），来研究学校生活对儿童和青少年 T1D 的影响。
这是一项回顾性研究，共纳入了 147 名使用间歇性扫描连续血糖监测（isCGM）系统的 T1D 患者（14-19 岁），这些患者在上学日和假期期间自行检测血糖水平。记录连续血糖监测（CGM）指标，即血糖变异性（GV）（%）、平均血糖达标时间（TIR）、血糖高于目标范围时间（TAR）、血糖低于目标范围时间（TBR）和低血糖事件的平均持续时间。
研究结果显示，假期和上学日的记录值存在差异，在 70-180mg/dL 目标范围内的百分比（%）（38.2% vs. 49.5%；p = 0.039）、平均血糖（194mg/dL vs. 185mg/dL；p = 0.048）、低血糖事件的频率（9.2 次/天 vs. 5.1 次/天；p = 0.036）、低血糖持续时间的平均值（117min vs. 65min；p = 0.021）、血糖低于 70mg/dL 的时间百分比（2.9% vs. 1.45%；p = 0.023）、血糖低于 54mg/dL 的时间百分比（1.1% vs. 0.51%；p = 0.031）、血糖在 181-250mg/dL 之间的时间百分比（21.1% vs. 16.5%；p = 0.037）和血糖高于 250mg/dL 的时间百分比（8.9% vs. 6.5%；p = 0.043）。与假期（8.34%）和上学日（8.13%）的糖化血红蛋白（HbA1c）水平相比，上学日的 HbA1c 水平较低，但假期和上学日之间的 HbA1c 水平无显著差异。关于 FreeStyle Libre（FSL）扫描，假期（n = 6.2）的扫描频率显著低于上学日（n = 9.5）（p = 0.042）。
研究结果表明，T1D 患儿在上学日的糖尿病控制较好，而在假期则较差。为了改善他们在假期的血糖控制，这些患者可能还需要更多的关注和指导。
