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蔬菜汁对牛肉提取物和亚硝化牛肉提取物致突变性的修饰作用。

Modifying action of vegetable juice on the mutagenicity of beef extract and nitrosated beef extract.

作者信息

Münzner R

出版信息

Food Chem Toxicol. 1986 Aug;24(8):847-9. doi: 10.1016/0278-6915(86)90075-x.

DOI:10.1016/0278-6915(86)90075-x
PMID:3536694
Abstract

The effect of juices of different vegetables on the mutagenicity of beef extract (with S-9 mix) and nitrosated beef extract (with and without S-9 mix) was examined using the Ames test. All the juices affected the induced mutagenicity of beef extract and nitrosated beef extract in the presence of S-9 mix, but not the mutagenicity of nitrosated beef extract in the absence of S-9 mix. As the vegetable juices appear to affect mutagenicity only in the presence of S-9 mix, it is concluded that the constituents of vegetables do not act directly on the mutagens; the effects are apparently caused by an interaction with the metabolic activation system.

摘要

使用艾姆斯试验检测了不同蔬菜汁对牛肉浸膏(含S - 9混合液)以及亚硝化牛肉浸膏(含和不含S - 9混合液)致突变性的影响。在有S - 9混合液存在的情况下,所有蔬菜汁均影响牛肉浸膏和亚硝化牛肉浸膏的诱导致突变性,但在没有S - 9混合液存在时,不影响亚硝化牛肉浸膏的致突变性。由于蔬菜汁似乎仅在有S - 9混合液存在时才影响致突变性,因此得出结论:蔬菜成分并非直接作用于诱变剂;这些影响显然是由与代谢活化系统的相互作用引起的。

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Food Chem Toxicol. 1986 Aug;24(8):847-9. doi: 10.1016/0278-6915(86)90075-x.
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The reaction of butylated hydroxyanisole and its metabolites with some arylamines: investigations of product mutagenicity.丁基羟基茴香醚及其代谢产物与某些芳胺的反应:产物致突变性研究。
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Vegetables, fruit, and cancer. I. Epidemiology.
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Cancer Causes Control. 1991 Sep;2(5):325-57. doi: 10.1007/BF00051672.