Chora Ângelo Ferreira, Mota Maria M, Prudêncio Miguel
Instituto de Medicina Molecular João Lobo Antunes, Fac. Medicina Univ. Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
Instituto de Medicina Molecular João Lobo Antunes, Fac. Medicina Univ. Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
Int J Parasitol. 2022 Oct;52(11):711-715. doi: 10.1016/j.ijpara.2022.02.002. Epub 2022 Mar 30.
While the liver and blood stages of the Plasmodium life cycle are commonly regarded as two separate fields of malaria research, several studies have pointed towards the existence of a bidirectional cross-talk, where one stage of mammalian infection may impact the establishment and progression of the other. Despite the constraints in experimentally addressing concurrent liver and blood stage Plasmodium infections, animal models and clinical studies have unveiled a plethora of molecular interactions between the two. Here, we review the current knowledge on the reciprocal influence of hepatic and erythrocytic infection by malaria parasites, and discuss its impacts on immunity, pathology and vaccination against this deadly disease.
虽然疟原虫生命周期的肝脏期和血液期通常被视为疟疾研究的两个独立领域，但多项研究表明存在双向交互作用，即哺乳动物感染的一个阶段可能会影响另一个阶段的建立和进展。尽管在实验上处理同时发生的肝脏期和血液期疟原虫感染存在限制，但动物模型和临床研究已经揭示了两者之间大量的分子相互作用。在此，我们综述了目前关于疟原虫肝脏感染和红细胞感染相互影响的知识，并讨论其对免疫、病理学以及针对这种致命疾病的疫苗接种的影响。
