Department of Pediatrics, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA.
Trends Parasitol. 2023 May;39(5):321-322. doi: 10.1016/j.pt.2023.03.004. Epub 2023 Mar 17.
Chora and colleagues show that infection of the liver by Plasmodium modulates severity of disease in the experimental cerebral malaria (ECM) model by generating gamma delta (ɣδ) T cells that produce IL-17. This work calls into question the long-standing assumption that liver infection does not modulate severity of malaria.
乔拉及其同事的研究表明，疟原虫感染肝脏会通过产生白细胞介素 17（IL-17）的 γδ（ɣδ）T 细胞来调节实验性脑疟疾（ECM）模型的疾病严重程度。这项工作对肝脏感染不调节疟疾严重程度的长期假设提出了质疑。
