肝期疟原虫感染影响临床结局。
Liver-stage Plasmodium infection tunes clinical outcomes.
机构信息
Department of Pediatrics, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA.
出版信息
Trends Parasitol. 2023 May;39(5):321-322. doi: 10.1016/j.pt.2023.03.004. Epub 2023 Mar 17.
Abstract
Chora and colleagues show that infection of the liver by Plasmodium modulates severity of disease in the experimental cerebral malaria (ECM) model by generating gamma delta (ɣδ) T cells that produce IL-17. This work calls into question the long-standing assumption that liver infection does not modulate severity of malaria.
摘要
乔拉及其同事的研究表明，疟原虫感染肝脏会通过产生白细胞介素 17（IL-17）的 γδ（ɣδ）T 细胞来调节实验性脑疟疾（ECM）模型的疾病严重程度。这项工作对肝脏感染不调节疟疾严重程度的长期假设提出了质疑。
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本文引用的文献
1
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Immunity. 2023 Mar 14;56(3):592-605.e8. doi: 10.1016/j.immuni.2023.01.031. Epub 2023 Feb 17.
2
The reciprocal influence of the liver and blood stages of the malaria parasite's life cycle.疟原虫生命周期中肝脏阶段与血液阶段的相互影响。
Int J Parasitol. 2022 Oct;52(11):711-715. doi: 10.1016/j.ijpara.2022.02.002. Epub 2022 Mar 30.
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