UC Berkeley School of Public Health, Berkeley, California.
Department of Dermatology, University of California, San Francisco School of Medicine (UCSF), San Francisco, California.
J Am Acad Dermatol. 2022 Aug;87(2):314-322. doi: 10.1016/j.jaad.2022.03.049. Epub 2022 Mar 31.
Chronic inflammatory conditions have been linked to dementia, but little is known about the role of atopic eczema, an inflammatory condition recently recognized to be common among older adults.
To determine whether active atopic eczema is associated with incident dementia.
A longitudinal cohort study of 1,767,667 individuals aged 60 to 99 years registered with The Health Improvement Network, a primary care cohort in the United Kingdom. The diagnoses of atopic eczema and dementia were identified using medical record codes.
The incidence of dementia was 57 per 10,000 person-years among those with atopic eczema during follow-up (12.1% of the population) compared with 44 per 10,000 person-years in the control group. This translated to a 27% increased risk of dementia (hazard ratio, 1.27; 95% CI, 1.23-1.30) in adjusted Cox proportional hazard models. Similar associations were observed in subgroup analyses of vascular dementia and Alzheimer's disease. The association persisted after additionally adjusting for the use of systemic corticosteroids (hazard ratio, 1.29; 95% CI, 1.26-1.33) and potential mediators (hazard ratio, 1.19; 95% CI, 1.16-1.22). More severe eczema was associated with a higher risk of dementia.
Lack of detailed data on severity.
Atopic eczema was associated with a small but increased risk of incident dementia. The association increased with the severity of atopic eczema.
慢性炎症状态与痴呆有关，但人们对特应性皮炎（一种新近被认为在老年人中常见的炎症状态）与痴呆的关系知之甚少。
确定特应性皮炎是否与痴呆的发生有关。
这是一项对登记于英国初级保健队列研究网络（The Health Improvement Network）的 1767667 名年龄在 60 至 99 岁人群进行的纵向队列研究。通过医疗记录代码确定特应性皮炎和痴呆的诊断。
在随访期间（占人群的 12.1%），有特应性皮炎的患者中痴呆的发生率为每 10000 人年 57 例，而对照组为每 10000 人年 44 例。这意味着调整后的 Cox 比例风险模型中痴呆的风险增加了 27%（风险比，1.27；95%置信区间，1.23-1.30）。在血管性痴呆和阿尔茨海默病的亚组分析中也观察到了类似的关联。在另外调整了全身皮质类固醇的使用（风险比，1.29；95%置信区间，1.26-1.33）和潜在的中介因素（风险比，1.19；95%置信区间，1.16-1.22）后，这种关联仍然存在。特应性皮炎越严重，痴呆的风险越高。
缺乏严重程度的详细数据。
特应性皮炎与痴呆发生的风险增加相关，且风险随特应性皮炎严重程度的增加而增加。
