衣霉素对酿酒酵母糖转运系统生物合成的抑制作用。
Inhibition of biosynthesis of Saccharomyces cerevisiae sugar transport system by tunicamycin.
作者信息
Lagunas R, DeJuan C, Benito B
出版信息
J Bacteriol. 1986 Dec;168(3):1484-6. doi: 10.1128/jb.168.3.1484-1486.1986.
Abstract
Tunicamycin apparently inhibited the biosynthesis of glucose, galactose, and maltose transport systems in Saccharomyces cerevisiae. Under the conditions used, the antibiotic also blocked the biosynthesis of invertase, a well-known yeast glycoprotein, as well as the glycosylation of a marker mannoprotein of the yeast cell wall. However, the antibiotic did not affect certain proteins which did not contain carbohydrate. It seems, therefore, that these sugar carriers are glycoproteins.
摘要
衣霉素明显抑制了酿酒酵母中葡萄糖、半乳糖和麦芽糖转运系统的生物合成。在所使用的条件下，这种抗生素还阻断了蔗糖酶（一种著名的酵母糖蛋白）的生物合成，以及酵母细胞壁标记甘露糖蛋白的糖基化。然而，这种抗生素并不影响某些不含碳水化合物的蛋白质。因此，这些糖载体似乎是糖蛋白。
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