甜菜根汁中的硝酸盐可降低动脉高血压患者的血压：一项系统评价和荟萃分析。
Nitrate Derived From Beetroot Juice Lowers Blood Pressure in Patients With Arterial Hypertension: A Systematic Review and Meta-Analysis.
作者信息
Benjamim Cicero Jonas R, Porto Andrey Alves, Valenti Vitor Engrácia, Sobrinho Andressa Crystine da Silva, Garner David M, Gualano Bruno, Bueno Júnior Carlos Roberto
机构信息
Department of Internal Medicine, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Autonomic Nervous System Center, UNESP, Marilia, Brazil.
出版信息
Front Nutr. 2022 Mar 15;9:823039. doi: 10.3389/fnut.2022.823039. eCollection 2022.
BACKGROUND
Although there are a considerable number of clinical studies on nitrate (NO) rich beetroot juice (BRJ) and hypertension, it is difficult to indicate the real effects of NO from BRJ on the BP of hypertensive patients because there are still no estimates of the effects of NO derived from BRJ on the BP of hypertension patients.
OBJECTIVE
To clarify these effects, we developed a systematic literature review with a meta-analysis of randomized clinical trials (RCTs).
DESIGN
The searches were accomplished through EMBASE, Cochrane Library, MEDLINE, CINAHL, Web of Science, and LILACS databases. The study included single or double-blinded RCTs and participants older than 18 years with hypertension [systolic BP (SBP) > 130 mmHg and diastolic BP (DBP) > 80 mmHg]. NO BRJ was required to be consumed in a format that possibly blinded participants/researchers. These studies should also report the SBP and DBP values (mmHg) measured before and after the treatment. Risk of Bias tools and GRADE were enforced.
RESULTS
Seven studies were included (218 participants). BRJ intervention time ranged from 3 to 60 days with daily dosages of 70-250 mL of BRJ. After the intervention with NO from BRJ, SBP underwent significant changes ( < 0.001) of -4.95 (95% CI: -8.88; -1.01) (GRADE: ⊕⊕⊕○ Moderate), but not for DBP ( = 0.06) -0.90 mmHg (95% CI: -3.16; 1.36) (GRADE: ⊕⊕⊕○ Moderate), compared to the control group.
CONCLUSIONS
The NO derived from BRJ reduces SBP, but not DBP in patients with arterial hypertension.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=269339.
背景
尽管有大量关于富含硝酸盐（NO）的甜菜根汁（BRJ）与高血压的临床研究，但由于仍未评估BRJ中NO对高血压患者血压的影响，因此很难表明BRJ中NO对高血压患者血压的实际作用。
目的
为阐明这些作用，我们开展了一项系统文献综述，并对随机临床试验（RCT）进行荟萃分析。
设计
通过EMBASE、Cochrane图书馆、MEDLINE、CINAHL、科学网和LILACS数据库进行检索。该研究纳入单盲或双盲RCT，以及年龄大于18岁的高血压患者[收缩压（SBP）>130 mmHg且舒张压（DBP）>80 mmHg]。要求以可能使参与者/研究人员不知情的方式饮用BRJ。这些研究还应报告治疗前后测量的SBP和DBP值（mmHg）。采用偏倚风险工具和GRADE分级。
结果
纳入7项研究（218名参与者）。BRJ干预时间为3至60天，每日剂量为70 - 250 mL BRJ。与对照组相比，用BRJ中的NO进行干预后，SBP发生显著变化（<0.001），变化值为-4.95（95%CI：-8.88；-1.01）（GRADE分级：⊕⊕⊕○ 中等），但DBP无显著变化（=0.06），变化值为-0.90 mmHg（95%CI：-3.16；1.36）（GRADE分级：⊕⊕⊕○ 中等）。
结论
BRJ中的NO可降低动脉高血压患者的SBP，但不能降低DBP。
系统综述注册
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=269339 。
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