Kotsuji F, Goto K, Aso T, Tominaga T
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Oct;38(10):1713-21.
Twelve-week-old female SD rats were restricted to an 8 g/day feed intake for 2 months followed by feeding ad libitum for 3 weeks. Feed restriction resulted in weight loss and constant diestrous. A persistent increase in the hypothalamic GnRH content was observed during the underfed period. Serum LH and PRL levels dropped throughout the period but the initial reduction in the serum FSH level was observed on the 60th day. The reductions in the pituitary content of these hormones were observed on the 30th day. The decrease in the serum and ovarian E2 levels were detected on the 14th day. Anterior pituitary showed a significant response to GnRH + TRH during the course, and the relative increases in LH, FSH and PRL were greater than those in the pretreatment rats. In the course of refeeding, the body weight returned to the control level and regular estrous cycles were reestablished on the 15th and 21st day, respectively. Elevated hypothalamic GnRH content returned to the control level on the 16th day. The changes in the pituitary-ovarian axis were prompt rebound rises in serum FSH and PRL levels and pituitary FSH content, delayed restoration of serum and pituitary LH levels and serum and ovarian E2 levels, and a marked increase in the serum and ovarian progesterone levels on the 16th day. The relative increases in FSH and PRL after GnRH + TRH injection were smaller than those in the underfed period.(ABSTRACT TRUNCATED AT 250 WORDS)
12周龄雌性SD大鼠被限制每日摄入8克饲料，持续2个月，随后自由进食3周。限食导致体重减轻和持续的乏情期。在限食期间观察到下丘脑促性腺激素释放激素（GnRH）含量持续增加。整个期间血清促黄体生成素（LH）和催乳素（PRL）水平下降，但在第60天观察到血清促卵泡生成素（FSH）水平开始降低。在第30天观察到这些激素的垂体含量减少。在第14天检测到血清和卵巢雌二醇（E2）水平下降。在此过程中，垂体前叶对GnRH +促甲状腺激素释放激素（TRH）有显著反应，LH、FSH和PRL的相对增加大于预处理大鼠。在重新喂食过程中，体重恢复到对照水平，分别在第15天和第21天重新建立规律的发情周期。下丘脑GnRH含量升高在第16天恢复到对照水平。垂体 - 卵巢轴的变化为血清FSH和PRL水平以及垂体FSH含量迅速反弹升高，血清和垂体LH水平以及血清和卵巢E2水平延迟恢复，并且在第16天血清和卵巢孕酮水平显著增加。GnRH + TRH注射后FSH和PRL的相对增加小于限食期间。（摘要截断于250字）
