Fujii T, Yamamoto N
Exp Aging Res. 1983 Fall;9(3):129-33. doi: 10.1080/03610738308258440.
Descendants of rats possessing lower responsiveness to the removal of the parathyroid gland [4] were examined for the aging process of the hypothalamic-pituitary-ovarian axis. The first generation rats of these descendants were born to mothers parathyroidectomized (Px) on the fifth day of gestation and subsequent generation rats were developed by brother-sister mating without any special treatment. More than 50% of the eighth to tenth generation (F8-F10) offsprings of the Px-rats showed regular 4-day estrous cycles at 15-16 months of age, while nearly 80% of normal F8-F10 rats developed persistent estrus at 13-14 months of age. In 14-15 month-old Px-offspring rats the LH and FSH surges occurred at 1630-1730 h of proestrus to a similar extent as those shown in 3-4 month-old normal rats. The release of LH and FSH following a single injection of luteinizing hormone-releasing hormone (LHRH) in 13 month-old Px-offspring rats was nearly normal, reaching a maximal level at 15 min as in young adult rats. In 13 month-old normal rats, serum LH measured after an injection of LHRH increased progressively until 60 min. The ovaries of the Px-offspring rats were heavier than those of age-matched normal rats and included well-developed corpora lutea and follicles in several sizes. The results suggest a delay in the aging process of the hypothalamic-pituitary-ovarian axis of the Px-offspring rats.
对甲状旁腺切除反应较低的大鼠的后代[4]进行了下丘脑 - 垂体 - 卵巢轴衰老过程的研究。这些后代的第一代大鼠由在妊娠第5天进行甲状旁腺切除（Px）的母鼠所生，后续代大鼠通过兄妹交配繁殖，未接受任何特殊处理。甲状旁腺切除大鼠的第八至第十代（F8 - F10）后代中，超过50%在15 - 16个月龄时呈现规律的4天发情周期，而正常F8 - F10大鼠中近80%在13 - 14个月龄时出现持续发情。在14 - 15月龄的甲状旁腺切除后代大鼠中，促卵泡生成素（LH）和促黄体生成素（FSH）高峰出现在发情前期的1630 - 1730时，其程度与3 - 4月龄正常大鼠相似。13月龄的甲状旁腺切除后代大鼠单次注射促黄体生成素释放激素（LHRH）后LH和FSH的释放近乎正常，与年轻成年大鼠一样在15分钟时达到最高水平。在13月龄的正常大鼠中，注射LHRH后测定的血清LH在60分钟前逐渐升高。甲状旁腺切除后代大鼠的卵巢比年龄匹配的正常大鼠的卵巢重，并且包含发育良好的黄体和几种不同大小的卵泡。结果表明甲状旁腺切除后代大鼠的下丘脑 - 垂体 - 卵巢轴衰老过程有所延迟。
