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碘苯甲酸酰肼功能化六钼酸盐对柯萨奇病毒B3的合成、表征及抑制活性

Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates.

作者信息

Wang Long-Sheng, Guo Chao, Hu Da, Zhao Yan-Xi, Liu Hui-Hui, Dong Yu-Jia, Sun Shang-Bin, Liu Xing, Hu Kang-Hong, Wei Yan-Hong

机构信息

School of Material and Chemical Engineering, Hubei University of Technology, Wuhan, China.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, CAS, Fuzhou, China.

出版信息

Front Chem. 2022 Mar 17;10:841151. doi: 10.3389/fchem.2022.841151. eCollection 2022.

DOI:10.3389/fchem.2022.841151
PMID:35372278
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8968398/
Abstract

A class of iodobenzoyldiazenido-functionalized POMs (TBA) [MoO(=N=NCOAr)] (Ar = Ph--I ; Ph--I ; Ph--I ; Ph-3,4-I ; Ph-2,3,5-I (TBA = tetrabutylammonium) were prepared the refluxing reaction of -octamolybdates, DCC, and corresponding hydrazides in dry acetonitrile. Their structures were determined by Fourier-transform infrared spectroscopy, ultraviolet-visible spectra, X-ray photoelectron spectroscopy, hydrogen-1 nuclear magnetic resonance, and high-resolution mass spectrometry. Research on the biological activity of title compounds shows that , , and demonstrate potent inhibitory activity against coxsackievirus B3 and low cytotoxic activity against Hep-2 cell lines. The covalent linkage between the iodobenzoyldiazenido components and POMs can enhance the molecular inhibitory efficiency of iodobenzohydrazides.

摘要

通过在干燥乙腈中使八钼酸盐、二环己基碳二亚胺（DCC）和相应的酰肼进行回流反应，制备了一类碘苯甲酰重氮基官能化的多金属氧酸盐（TBA）[MoO(=N=NCOAr)]（Ar = Ph--I；Ph--I；Ph--I；Ph-3,4-I；Ph-2,3,5-I （TBA = 四丁基铵）。通过傅里叶变换红外光谱、紫外可见光谱、X射线光电子能谱、氢-1核磁共振和高分辨率质谱确定了它们的结构。对标题化合物生物活性的研究表明， 、 和 对柯萨奇病毒B3表现出强效抑制活性，对Hep-2细胞系表现出低细胞毒性活性。碘苯甲酰重氮基组分与多金属氧酸盐之间的共价连接可以提高碘苯酰肼的分子抑制效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b23/8968398/05b25ad4c2ee/fchem-10-841151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b23/8968398/b643879bbac5/fchem-10-841151-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b23/8968398/d6eceb7d62be/fchem-10-841151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b23/8968398/05b25ad4c2ee/fchem-10-841151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b23/8968398/b643879bbac5/fchem-10-841151-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b23/8968398/d6eceb7d62be/fchem-10-841151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b23/8968398/05b25ad4c2ee/fchem-10-841151-g002.jpg

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