Gridnev Artem, Misra Jyoti R
Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, United States.
Front Cell Dev Biol. 2022 Mar 16;10:842593. doi: 10.3389/fcell.2022.842593. eCollection 2022.
Dachsous (Ds) and Fat are evolutionarily conserved cell adhesion molecules that play a critical role in development of multiple organ systems, where they coordinate tissue growth and morphogenesis. Much of our understanding of Ds-Fat signaling pathway comes from studies in , where they initiate a signaling pathway that regulate growth by influencing Hippo signaling and morphogenesis by regulating Planar Cell Polarity (PCP). In this review, we discuss recent advances in our understanding of the mechanisms by which Ds-Fat signaling pathway regulates these critical developmental processes. Further, we discuss the progress in our understanding about how they function in mammals.
达索（Ds）和Fat是进化上保守的细胞粘附分子，在多个器官系统的发育中起关键作用，它们在其中协调组织生长和形态发生。我们对Ds-Fat信号通路的许多了解来自于对[具体研究对象]的研究，在这些研究中，它们启动了一条信号通路，该通路通过影响Hippo信号来调节生长，并通过调节平面细胞极性（PCP）来调节形态发生。在这篇综述中，我们讨论了我们对Ds-Fat信号通路调节这些关键发育过程的机制的最新理解进展。此外，我们还讨论了我们对它们在哺乳动物中如何发挥作用的理解进展。
