Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Psychiatry and Behavioral Sciences Research Center, Addiction institute, Mazandaran University of Medical Sciences, Sari, Iran.
Neuropsychopharmacol Rep. 2022 Sep;42(3):368-373. doi: 10.1002/npr2.12251. Epub 2022 Apr 3.
Sinus tachycardia and orthostatic hypotension have been so far reported among the negative cardiovascular complications of antipsychotic agents. This study aimed to report a case with bradycardia induced by fluphenazine decanoate administration. The patient was a 29-year-old man, admitted to the general teaching hospital in Sari, Iran, with a complaint of abdominal and gastric pain as well as weight loss following 7 months of fasting based on religious delusions. The patient developed bradycardia, 36 hours after fluphenazine decanoate administration. His pulse rate was also 46 beats per min (bpm). The antipsychotic medication was thus held and the patient did not take any drugs. On the 21st day after discontinuing this agent, the pulse rate reached 70 bpm. This case report notifies that much more attention should be paid to all patients before starting fluphenazine decanoate administration, and close cardiac monitoring must be done.
迄今为止，抗精神病药物的心血管不良并发症已包括窦性心动过速和体位性低血压。本研究旨在报告一例氟奋乃静癸酸酯给药引起的心动过缓病例。患者为一名 29 岁男性，因宗教妄想而禁食 7 个月后，出现腹痛、胃部疼痛和体重减轻，入住伊朗萨里的一所教学综合医院。氟奋乃静癸酸酯给药 36 小时后，患者出现心动过缓，心率为 46 次/分。抗精神病药物因此被停用，且患者未服用任何药物。停用该药物后第 21 天，心率达到 70 次/分。本病例报告提醒，在开始氟奋乃静癸酸酯给药前，应更加关注所有患者，并且必须进行密切的心脏监测。
