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宫腔镜治疗宫腔粘连后的生殖性能:单外科医生数据。

Reproductive performance following hysteroscopic treatment of intrauterine adhesions: single surgeon data.

作者信息

Direk L S, Salman M, Alchami A, Saridogan E

出版信息

Facts Views Vis Obgyn. 2022 Mar;14(1):51-58. doi: 10.52054/FVVO.14.1.005.

DOI:10.52054/FVVO.14.1.005
PMID:35373548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9612855/
Abstract

BACKGROUND

Intrauterine adhesions can negatively affect reproductive outcomes by causing infertility, miscarriage and preterm birth in women. Hysteroscopic surgery is now widely accepted as the treatment of choice in symptomatic women to restore reproductive function.

OBJECTIVES

To analyse the patient characteristics and long-term reproductive outcomes of women who received treatment for intrauterine adhesions under the care of a single surgeon.

MATERIALS AND METHODS

In this retrospective analysis, all women who underwent hysteroscopic surgery for intrauterine adhesions under the care of the same surgeon between January 2001 and December 2019 were identified and their data were evaluated. Relevant demographic, diagnostic and reproductive outcome data was procured from patient notes. Referring doctors and patients were contacted to obtain missing information.

MAIN OUTCOME MEASURES

Live birth and miscarriage rates.

RESULTS

126 women were treated for intrauterine adhesions. Of those women who were trying to conceive, 71.4% (65/91) achieved pregnancy, 58.2% (53/91) had live births and 13.2% (12/91) had miscarriages. No statistically significant difference was found in the live birth rates when data was analysed in subgroups based on age, reason for referral/aetiology and severity of pathology.

CONCLUSIONS

Hysteroscopic surgery leads to live birth in the majority of women with intrauterine adhesions. The lack of statistically significant difference in live birth rates across subgroups, including advanced age and severe pathology, suggests that surgery in all women wanting to conceive can be justified.

WHAT IS NEW?: Hysteroscopic treatment can lead to successful outcomes even in the presence of severe adhesions and in older women with appropriate treatment.

摘要

背景

宫腔粘连会对女性生殖结局产生负面影响,导致不孕、流产和早产。宫腔镜手术目前已被广泛接受为有症状女性恢复生殖功能的首选治疗方法。

目的

分析在单一外科医生治疗下接受宫腔粘连治疗的女性患者特征和长期生殖结局。

材料与方法

在这项回顾性分析中,确定了2001年1月至2019年12月期间在同一位外科医生治疗下接受宫腔镜手术治疗宫腔粘连的所有女性,并对其数据进行评估。从患者病历中获取相关的人口统计学、诊断和生殖结局数据。联系转诊医生和患者以获取缺失信息。

主要观察指标

活产率和流产率。

结果

126名女性接受了宫腔粘连治疗。在那些试图怀孕的女性中,71.4%(65/91)实现了妊娠,58.2%(53/91)活产,13.2%(12/91)流产。根据年龄、转诊原因/病因和病理严重程度对数据进行亚组分析时,活产率没有发现统计学上的显著差异。

结论

宫腔镜手术使大多数宫腔粘连女性实现了活产。各亚组(包括高龄和严重病理情况)的活产率缺乏统计学上的显著差异,这表明所有想要怀孕的女性进行手术都是合理的。

新发现是什么?:即使存在严重粘连且年龄较大的女性接受适当治疗,宫腔镜治疗也能取得成功的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78eb/9612855/e9842e882be9/FVVinObGyn-14-51-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78eb/9612855/73665f0db1e5/FVVinObGyn-14-51-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78eb/9612855/ee9ce3c18707/FVVinObGyn-14-51-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78eb/9612855/e9842e882be9/FVVinObGyn-14-51-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78eb/9612855/73665f0db1e5/FVVinObGyn-14-51-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78eb/9612855/ee9ce3c18707/FVVinObGyn-14-51-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78eb/9612855/e9842e882be9/FVVinObGyn-14-51-g003.jpg

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本文引用的文献

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2
Live births after Asherman syndrome treatment.Asherman 综合征治疗后的活产儿。
Fertil Steril. 2021 Oct;116(4):1181-1187. doi: 10.1016/j.fertnstert.2021.05.099. Epub 2021 Jun 12.
3
Multiple myomectomy to aid fertility treatment - surgical and fertility outcomes: a retrospective cohort study.多次子宫肌瘤切除术辅助生育治疗——手术及生育结局:一项回顾性队列研究
Facts Views Vis Obgyn. 2021 Jan 8;12(4):283-289.
4
Adhesions and Anti-Adhesion Systems Highlights.粘连与抗粘连系统要点
Facts Views Vis Obgyn. 2019 Jun;11(2):137-149.
5
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Hum Reprod. 2018 Oct 1;33(10):1847-1853. doi: 10.1093/humrep/dey237.
6
Are synechiae a complication of laparotomic myomectomy?腹式子宫肌瘤剔除术是否会导致粘连?
Reprod Biomed Online. 2018 Apr;36(4):450-454. doi: 10.1016/j.rbmo.2018.01.010. Epub 2018 Feb 2.
7
AAGL practice report: practice guidelines on intrauterine adhesions developed in collaboration with the European Society of Gynaecological Endoscopy (ESGE).美国妇科腹腔镜医师协会实践报告:与欧洲妇科内镜学会(ESGE)合作制定的宫腔粘连实践指南。
Gynecol Surg. 2017;14(1):6. doi: 10.1186/s10397-017-1007-3. Epub 2017 May 1.
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Surgical treatment of fibroids in heavy menstrual bleeding.月经过多的子宫肌瘤手术治疗。
Womens Health (Lond). 2016 Jan;12(1):53-62. doi: 10.2217/whe.15.89. Epub 2015 Dec 23.
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Results of centralized Asherman surgery, 2003-2013.2003 - 2013年宫腔粘连集中手术的结果
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Ultrasound Obstet Gynecol. 2015 Aug;46(2):131-9. doi: 10.1002/uog.14927. Epub 2015 Jul 20.