肼对DNA的降解作用：3-脲基吡唑作为脱氧胞苷酸残基肼解产物的鉴定。
The degradation of DNA by hydrazine: identification of 3-ureidopyrazole as a product of the hydrazinolysis of deoxycytidylic acid residues.
作者信息
Cashmore A R, Petersen G B
出版信息
Nucleic Acids Res. 1978 Jul;5(7):2485-91. doi: 10.1093/nar/5.7.2485.
Abstract
The reaction of hydrazine with the cytosine residues of DNA yields 3-ureidopyrazole, in approximately 50% yield, in addition to the expected 3-aminopyrazole. This product has been identified by ultraviolet, infrared, nuclear magnetic resonance and mass spectroscopy. A product of the reaction of hydrazine hydrate with cytosine, formulated by others as NN'-di-(3-pyrazolyl) hydrazine, has been identified as 3-ureidopyrazole.
摘要
肼与DNA的胞嘧啶残基反应，除了生成预期的3-氨基吡唑外，还以约50%的产率生成3-脲基吡唑。该产物已通过紫外、红外、核磁共振和质谱鉴定。水合肼与胞嘧啶反应的一种产物，其他人将其配制成NN'-二-(3-吡唑基)肼，已被鉴定为3-脲基吡唑。
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