• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The degradation of DNA by hydrazine: identification of 3-ureidopyrazole as a product of the hydrazinolysis of deoxycytidylic acid residues.肼对DNA的降解作用：3-脲基吡唑作为脱氧胞苷酸残基肼解产物的鉴定。
Nucleic Acids Res. 1978 Jul;5(7):2485-91. doi: 10.1093/nar/5.7.2485.
2
The degradation of DNA by hydrazine: a critical study of the suitability of the reaction for the quantitative determination of purine nucleotide sequences.肼对DNA的降解作用：对该反应用于嘌呤核苷酸序列定量测定适用性的关键研究。
Biochim Biophys Acta. 1969 Feb 18;174(2):591-603. doi: 10.1016/0005-2787(69)90289-5.
3
[Preparation and alkali hydrolysis of apyrimidinic DNA].[无嘧啶DNA的制备及碱水解]
Biokhimiia. 1969 May-Jun;34(3):546-55.
4
[PIEZOELECTRIC RESONANCE OF NUCLEIC ACIDS AND THEIR CONSTITUENTS].[核酸及其成分的压电共振]
C R Hebd Seances Acad Sci. 1963 Sep 2;257:1724-7.
5
Studies on the nucleotide arrangement in deoxyribonucleic acids. 13. Frequency and composition of purine isostichs in calf-thymus deoxyribonucleic acid.脱氧核糖核酸中核苷酸排列的研究。13. 小牛胸腺脱氧核糖核酸中嘌呤同列核苷酸的频率和组成。
Biochim Biophys Acta. 1969 Dec 16;195(2):456-65.
6
Loss of adenine during the hydrazine degradation of deoxyribonucleic acid.脱氧核糖核酸在肼降解过程中腺嘌呤的损失。
Nature. 1966 Jun 11;210(5041):1159-60. doi: 10.1038/2101159b0.
7
Hydrazine derivatives of L-ascorbic acid and of its D-erythro and phenyl analogs.L-抗坏血酸及其D-赤藓糖型和苯基类似物的肼衍生物。
Carbohydr Res. 1977 Jun;56(1):200-6. doi: 10.1016/s0008-6215(00)84256-1.
8
Reaction of methyl 2-(2',2'-bis(carbethoxy)vinylamino)benzoate with hydrazine.2-（2'，2'-双（乙氧羰基）乙烯基氨基）苯甲酸甲酯与肼的反应。
J Pharm Sci. 1973 May;62(5):834-5. doi: 10.1002/jps.2600620535.
9
On the stability of the guanine-cytosine hydrogen bond.论鸟嘌呤 - 胞嘧啶氢键的稳定性
Experientia. 1964 Jan 15;20(1):14-6. doi: 10.1007/BF02146015.
10
Interaction of oxidized polyamines with DNA. IV. Effect of DNA composition on the binding.氧化多胺与DNA的相互作用。IV. DNA组成对结合的影响。
Biochim Biophys Acta. 1969 Apr 22;179(2):473-83.

引用本文的文献

1
Conversion of phenylalanine into tyrosine by portulaca callus.马齿苋愈伤组织将苯丙氨酸转化为酪氨酸。
Plant Physiol. 1981 Aug;68(2):272-4. doi: 10.1104/pp.68.2.272.
2
Analysis of mRNA 3' end formation by modification interference: the only modifications which prevent processing lie in AAUAAA and the poly(A) site.通过修饰干扰分析mRNA 3'端的形成：唯一阻止加工的修饰位于AAUAAA和聚腺苷酸化位点。
EMBO J. 1987 Dec 20;6(13):4177-84. doi: 10.1002/j.1460-2075.1987.tb02764.x.
3
Direct chemical method for sequencing RNA.RNA测序的直接化学方法。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1760-4. doi: 10.1073/pnas.76.4.1760.

本文引用的文献

1
STUDIES OF THE NUCLEOTIDE ARRANGEMENT IN DEOXYRIBONUCLEIC ACIDS. IX. SELECTIVE DEGRADATION OF PYRIMIDINE DEOXYRIBONUCLEOTIDES.脱氧核糖核酸中核苷酸排列的研究。IX. 嘧啶脱氧核苷酸的选择性降解
Biochim Biophys Acta. 1964 Nov 15;91:462-76. doi: 10.1016/0926-6550(64)90076-3.
2
Hydrazinolysis of some purines and pyrimidines and their related nucleosides and nucleotides.某些嘌呤、嘧啶及其相关核苷和核苷酸的肼解反应。
J Chem Soc Perkin 1. 1967;16:1528-33. doi: 10.1039/j39670001528.
3
Selective reaction of methoxyamine with cytosine bases in tyrosine transfer ribonucleic acid.甲氧基胺与酪氨酸转移核糖核酸中胞嘧啶碱基的选择性反应。
J Mol Biol. 1971 Jul 28;59(2):359-73. doi: 10.1016/0022-2836(71)90056-8.
4
The degradation of DNA by hydrazine: a critical study of the suitability of the reaction for the quantitative determination of purine nucleotide sequences.肼对DNA的降解作用：对该反应用于嘌呤核苷酸序列定量测定适用性的关键研究。
Biochim Biophys Acta. 1969 Feb 18;174(2):591-603. doi: 10.1016/0005-2787(69)90289-5.
5
Mapping adenines, guanines, and pyrimidines in RNA.绘制RNA中的腺嘌呤、鸟嘌呤和嘧啶。
Nucleic Acids Res. 1977 Aug;4(8):2527-38. doi: 10.1093/nar/4.8.2527.
6
A new method for sequencing DNA.一种新的DNA测序方法。
Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4. doi: 10.1073/pnas.74.2.560.
7
The mechanism of the mutagenic action of hydroxylamines.羟胺的诱变作用机制。
Prog Nucleic Acid Res Mol Biol. 1976;16:125-88. doi: 10.1016/s0079-6603(08)60757-6.

肼对DNA的降解作用：3-脲基吡唑作为脱氧胞苷酸残基肼解产物的鉴定。

The degradation of DNA by hydrazine: identification of 3-ureidopyrazole as a product of the hydrazinolysis of deoxycytidylic acid residues.

作者信息

Cashmore A R, Petersen G B

出版信息

Nucleic Acids Res. 1978 Jul;5(7):2485-91. doi: 10.1093/nar/5.7.2485.

DOI:10.1093/nar/5.7.2485
PMID:353742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342178/
Abstract

The reaction of hydrazine with the cytosine residues of DNA yields 3-ureidopyrazole, in approximately 50% yield, in addition to the expected 3-aminopyrazole. This product has been identified by ultraviolet, infrared, nuclear magnetic resonance and mass spectroscopy. A product of the reaction of hydrazine hydrate with cytosine, formulated by others as NN'-di-(3-pyrazolyl) hydrazine, has been identified as 3-ureidopyrazole.

摘要

肼与DNA的胞嘧啶残基反应，除了生成预期的3-氨基吡唑外，还以约50%的产率生成3-脲基吡唑。该产物已通过紫外、红外、核磁共振和质谱鉴定。水合肼与胞嘧啶反应的一种产物，其他人将其配制成NN'-二-(3-吡唑基)肼，已被鉴定为3-脲基吡唑。