Tulandi T, Kinch R A, Lal S
Maturitas. 1986 Oct;8(3):197-200. doi: 10.1016/0378-5122(86)90026-5.
The effect of guanfacine (0.5 mg/day), an alpha-adrenergic agonist, on menopausal flushing, was studied in a double-blind, placebo-controlled crossover study in 11 patients. Both guanfacine and placebo significantly decreased the total number of flushes from baseline values. There was, however, no significant difference between placebo and guanfacine. Larger doses of guanfacine may be required to exert a therapeutic effect similar to that reported in the literature with the alpha-adrenergic agents, clonidine and alpha-methyldopa.
在一项针对11名患者的双盲、安慰剂对照交叉研究中，研究了α-肾上腺素能激动剂胍法辛（0.5毫克/天）对更年期潮热的影响。胍法辛和安慰剂均使潮热总数较基线值显著减少。然而，安慰剂和胍法辛之间无显著差异。可能需要更大剂量的胍法辛才能发挥与文献中报道的α-肾上腺素能药物可乐定和α-甲基多巴类似的治疗效果。
