Snow M H, Jachuck S J, Robson V, Wilkinson R
Postgrad Med J. 1978 May;54(631):311-7. doi: 10.1136/pgmj.54.631.311.
Plasma renin activity (PRA) was studied serially for up to 21 days following transplantation in thirteen patients receiving renal allografts. PRA was measured during fasting and recumvency and its relationship to renal function, diuretic administration, plasma sodium, allograft rejection and blood pressure was examined. PRA fell steadily as renal function improved and plasma sodium rose following transplantation and when rejection episodes were excluded an inverse relationship between PRA and renal function could be seen. It is not possible to say whether the changes in PRA and function are causally related or whether changes in plasma sodium alone account for the observed changes in PRA. Some rejection episodes were accompanied by an increase in PRA, but this was not sufficiently consistent to be of value in the diagnosis of rejection. PRA also increased in relation to frusemide-induced fluid loss. There was no relationship in these patients between PRA and blood pressure.
对13例接受同种异体肾移植的患者，在移植后连续21天对血浆肾素活性（PRA）进行了研究。在空腹和卧位时测量PRA，并检查其与肾功能、利尿剂使用、血浆钠、移植肾排斥反应和血压的关系。随着移植后肾功能改善和血浆钠升高，PRA稳步下降，排除排斥反应发作后，可观察到PRA与肾功能呈负相关。无法确定PRA和功能的变化是否存在因果关系，或者仅仅是血浆钠的变化导致了观察到的PRA变化。一些排斥反应发作伴有PRA升高，但这并不足够一致，对排斥反应的诊断没有价值。PRA也因速尿引起的液体丢失而增加。这些患者的PRA与血压之间没有关系。
