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半乳糖凝集素-8 和 -9 作为宫颈癌的预后因素。

Galectin-8 and -9 as prognostic factors for cervical cancer.

机构信息

Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Institute of Pathology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

出版信息

Arch Gynecol Obstet. 2022 Oct;306(4):1211-1220. doi: 10.1007/s00404-022-06449-9. Epub 2022 Apr 4.

DOI:10.1007/s00404-022-06449-9
PMID:35377045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9470666/
Abstract

PURPOSE

Galectins are carbohydrate-binding proteins with multiple effects on cell biology. Research shows that they play an important role in tumor development and progression. Therefore, in this study, the presence of Galectin-8 and -9 (Gal), both already known as prognostic factors in other tumor entities, were investigated in cervical cancer. Our aim was to examine the association of Gal-8 and -9 expression with histopathological markers and survival of the patients.

METHODS

Gal-8 and -9 expression was investigated in 250 cervical cancer samples by immunohistochemistry. The staining was evaluated using the immunoreactive score (IRS). The results were correlated to clinical and pathological data. The correlation of Gal-8 and -9 expression with overall and relapse-free survival was analyzed.

RESULTS

Expression of Gal-8 was associated with negative N-status and lower FIGO status. Detection of Gal-9 was connected to negative N-status and lower grading regarding all specimens. A correlation of Gal-9 with lower FIGO status was detected for squamous cell carcinoma (SCC) only. Expression of Gal-8 was associated with relapse-free survival of SCC patients in a positive manner. Gal-9 expression was associated with better overall survival.

CONCLUSION

Our results suggest that expression of both galectins is inversely associated with tumor stage and progression. Gal-8 expression is associated with relapse-free survival of patients with SCC, while presence of Gal-9 in cervical cancer is associated with a better prognosis in regard of overall survival.

摘要

目的

半乳糖凝集素是具有多种细胞生物学效应的糖结合蛋白。研究表明，它们在肿瘤的发生和发展中起着重要作用。因此，在这项研究中，研究了半乳糖凝集素-8 和 -9（Gal）在宫颈癌中的存在，这两种蛋白在其他肿瘤实体中已经被认为是预后因素。我们的目的是研究 Gal-8 和 -9 表达与组织病理学标志物和患者生存的关系。

方法

采用免疫组织化学法检测 250 例宫颈癌组织中 Gal-8 和 -9 的表达。采用免疫反应评分（IRS）评估染色结果。将结果与临床病理资料进行相关性分析。分析 Gal-8 和 -9 表达与总生存和无复发生存的相关性。

结果

Gal-8 的表达与 N 分期阴性和 FIGO 分期较低有关。所有标本中检测到 Gal-9 的表达与 N 分期阴性和分级较低有关。仅在鳞癌（SCC）中检测到 Gal-9 与较低的 FIGO 分期有关。Gal-8 的表达与 SCC 患者的无复发生存呈正相关。Gal-9 的表达与总生存较好相关。

结论

我们的研究结果表明，两种半乳糖凝集素的表达与肿瘤分期和进展呈负相关。Gal-8 的表达与 SCC 患者的无复发生存相关，而宫颈癌中 Gal-9 的存在与总生存预后较好相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfd/9470666/ff28e4abb64d/404_2022_6449_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfd/9470666/0cf53503223d/404_2022_6449_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfd/9470666/ee2ea82147b7/404_2022_6449_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfd/9470666/ff28e4abb64d/404_2022_6449_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfd/9470666/0cf53503223d/404_2022_6449_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfd/9470666/ee2ea82147b7/404_2022_6449_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddfd/9470666/ff28e4abb64d/404_2022_6449_Fig3_HTML.jpg

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