Amatya Neetu, Paudel Govinda, Saud Bhuvan, Wagle Sunita, Shrestha Vikram, Adhikari Bibhav
Department of Medical Laboratory Technology, Janamaitri Foundation Institute of Health Sciences (JFIHS), G.P.O. Box 8322, Kathmandu, Nepal.
Dhading Hospital, Dhading, Government of Nepal, Kathmandu, Nepal.
Interdiscip Perspect Infect Dis. 2022 Mar 26;2022:3989781. doi: 10.1155/2022/3989781. eCollection 2022.
causes mild to severe disease in all age groups, mainly in children. This study investigates the prevalence of , its cocolonization with other common nasal flora, and associated risk factors in kindergarten children in Bhaktapur.
A cross-sectional study was conducted among 136 healthy school-going children from four kindergartens of Bhaktapur Municipality. Nasal swabs were examined for identification and isolation of and its antibiotic susceptibility pattern. Additionally, further analysis was performed for cocolonization and associated risk factors.
Out of 136 students, was detected in 80 (58.8%) children. Using bivariate and multivariate analysis, the associated risk factors with significantly high carriage rates were age group of 3-4 years, classroom occupancy with 15-30 children, and antibiotic consumption within 6 months, with a value of ≤0.05 in each of the cases. Multiple logistic regression analysis of bacterial coexistence depicted to be positively associated with and and negatively associated with . Furthermore, the highest double colonization occurred among and and the highest triple colonization occurred among , , and . The antibiogram pattern showed the target organisms to be highly resistant to amoxycillin/clavulanate (18.8%) and most sensitive to chloramphenicol (100%).
This study shows a high prevalence of in healthy kindergarten children and is positively associated with other nasal isolates like and .
在所有年龄组中均可引起轻至重度疾病，主要发生在儿童中。本研究调查了巴克塔普尔幼儿园儿童中[具体病菌名称]的流行情况、其与其他常见鼻腔菌群的共定植情况以及相关危险因素。
对来自巴克塔普尔市四个幼儿园的136名健康学龄儿童进行了一项横断面研究。对鼻拭子进行检查，以鉴定和分离[具体病菌名称]及其抗生素敏感性模式。此外，还对共定植情况和相关危险因素进行了进一步分析。
在136名学生中，80名（58.8%）儿童检测出[具体病菌名称]。通过二元和多变量分析，携带率显著较高的相关危险因素为3 - 4岁年龄组、班级容纳15 - 30名儿童以及6个月内使用过抗生素，每种情况的P值均≤0.05。细菌共存的多元逻辑回归分析表明，[具体病菌名称]与[其他病菌名称1]和[其他病菌名称2]呈正相关，与[其他病菌名称3]呈负相关。此外，[具体病菌名称]与[其他病菌名称1]之间的双重定植率最高，[具体病菌名称]、[其他病菌名称1]和[其他病菌名称2]之间的三重定植率最高。抗菌谱模式显示目标生物体对阿莫西林/克拉维酸高度耐药（18.8%），对氯霉素最敏感（100%）。
本研究表明健康幼儿园儿童中[具体病菌名称]的流行率较高，且与[其他病菌名称1]和[其他病菌名称2]等其他鼻腔分离株呈正相关。
