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乳腺癌中CENP家族表达及预后意义的综合分析

Comprehensive Analysis of the Expression and Prognostic Significance of the CENP Family in Breast Cancer.

作者信息

Liu Xueliang, Liu Yunjiang

机构信息

Breast Cancer Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, People's Republic of China.

出版信息

Int J Gen Med. 2022 Mar 29;15:3471-3482. doi: 10.2147/IJGM.S354200. eCollection 2022.

DOI:10.2147/IJGM.S354200
PMID:35378917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8976518/
Abstract

BACKGROUND

Centromere proteins (CENPs) are a set of protein-coding genes involved in the transient assembly of the kinetochore which occurs during mitosis. This study intended to clarify the expression patterns, prognosis and potential mechanisms of CENPs in breast cancer (BC).

METHODS

Coexpedia was used to screen GEO datasets and PubMed articles related to CENPs and BC. CENPs expressions, prognosis and alteration were analyzed by Oncomine, Ualcan and Kaplan Meier plotter and cBioPortal. The correlation and interaction of CENPs was performed by Breast Cancer Gene-Expression Miner, GeneMANIA and STRING portal. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were conducted to clarify the functional roles of CENPs. CENPF, E, U, A, N, I, K, W, M, L were selected for further analysis.

RESULTS

All CENPs were highly expressed in BC compared to normal tissue. High expression of CENPF, E, U, A, N, I, W, M, L and CENPF, E, U, A, N, I, M correlated with worse relapse free survival (RFS) and worse overall survival (OS), respectively. All of 10 CENPs indicated positive correlations and complex interactions between each other at mRNA expression and protein level. CENPs were enriched GO terms mainly in centromere complex assembly and KEGG terms in progesterone-mediated oocyte maturation, cell cycle and oocyte meiosis.

CONCLUSION

The 10 CENPs could be diagnostic biomarkers and all of them except CENPK can be used as prognosis biomarkers in BC. CENPs play an oncogenic role and may be the potential therapy targets of treatment for BC patients.

摘要

背景

着丝粒蛋白（CENPs）是一组蛋白质编码基因，参与有丝分裂期间发生的动粒的瞬时组装。本研究旨在阐明CENPs在乳腺癌（BC）中的表达模式、预后及潜在机制。

方法

使用Coexpedia筛选与CENPs和BC相关的GEO数据集及PubMed文章。通过Oncomine、Ualcan、Kaplan Meier plotter和cBioPortal分析CENPs的表达、预后及改变情况。利用乳腺癌基因表达挖掘器、GeneMANIA和STRING门户进行CENPs的相关性和相互作用分析。进行基因本体论（GO）和京都基因与基因组百科全书（KEGG）富集分析以阐明CENPs的功能作用。选择CENPF、E、U、A、N、I、K、W、M、L进行进一步分析。

结果

与正常组织相比，所有CENPs在BC中均高表达。CENPF、E、U、A、N、I、W、M、L的高表达以及CENPF、E、U、A、N、I、M的高表达分别与无复发生存期（RFS）较差和总生存期（OS）较差相关。10种CENPs在mRNA表达和蛋白质水平上均显示出正相关及复杂的相互作用。CENPs在GO术语中主要富集于着丝粒复合体组装，在KEGG术语中富集于孕酮介导的卵母细胞成熟、细胞周期和卵母细胞减数分裂。

结论

这10种CENPs可作为诊断生物标志物，除CENPK外，所有这些CENPs均可作为BC的预后生物标志物。CENPs发挥致癌作用，可能是BC患者治疗的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/943c45f52555/IJGM-15-3471-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/4e8ab3dcad17/IJGM-15-3471-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/7144174a736a/IJGM-15-3471-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/9821f6966d16/IJGM-15-3471-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/33156dcb5909/IJGM-15-3471-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/a18dd58aef90/IJGM-15-3471-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/5e2aa1b757f5/IJGM-15-3471-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/943c45f52555/IJGM-15-3471-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/4e8ab3dcad17/IJGM-15-3471-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/7144174a736a/IJGM-15-3471-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/9821f6966d16/IJGM-15-3471-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/33156dcb5909/IJGM-15-3471-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/a18dd58aef90/IJGM-15-3471-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/5e2aa1b757f5/IJGM-15-3471-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/511a/8976518/943c45f52555/IJGM-15-3471-g0007.jpg

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The novel interaction mode among centromere sub-complex CENP-O/P/U/Q/R.着丝粒亚复合体 CENP-O/P/U/Q/R 的新型相互作用模式。
KHSRP 具有致癌功能，并调节乳腺癌 MDA-MB-231 细胞中 DNA 修复基因的表达和选择性剪接。
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Expression profiling of luminal B breast tumor in Indian women.印度女性管腔B型乳腺肿瘤的表达谱分析。
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