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日本脑炎感染所致认知障碍患者的蛋白质组学亚型及临床预后

Proteomic landscape subtype and clinical prognosis of patients with the cognitive impairment by Japanese encephalitis infection.

作者信息

Yin Rong, Yang Linpeng, Hao Ying, Yang Zhiqi, Lu Tao, Jin Wanjun, Dan Meiling, Peng Liang, Zhang Yingjie, Wei Yaxuan, Li Rong, Ma Huiping, Shi Yuanyuan, Fan Pengcheng

机构信息

Department of Neurology, Lanzhou General Hospital, Lanzhou, 730050, China.

Department of Neurology, Gansu Province Central Hospital, Lanzhou, 730070, China.

出版信息

J Neuroinflammation. 2022 Apr 4;19(1):77. doi: 10.1186/s12974-022-02439-5.

DOI:10.1186/s12974-022-02439-5
PMID:35379280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8981687/
Abstract

BACKGROUND

Cognitive impairment is one of the primary sequelae affecting the quality of life of patients with Japanese encephalitis (JE). The clinical treatment is mainly focused on life support, lacking of targeted treatment strategy.

METHODS

A cerebrospinal fluid (CSF) proteomic profiling study was performed including 26 patients with JE in Gansu province of China from June 2017 to October 2018 and 33 other concurrent hospitalized patients who were excluded central nervous system (CNS) organic or CNS infection diseases. The clinical and proteomics data of patients with JE were undergoing combined analysis for the first time.

RESULTS

Two subtypes of JE associated with significantly different prognoses were identified. Compared to JE1, the JE2 subtype is associated with lower overall survival rate and a higher risk of cognitive impairment. The percentages of neutrophils (N%), lymphocyte (L%), and monocytes (M%) decreased in JE2 significantly.

CONCLUSIONS

The differences in proteomic landscape between JE subgroups have specificity for the prognosis of cognitive impairment. The data also provided some potential target proteins for treatment of cognitive impairments caused by JE. Trial registration ChiCTR, ChiCTR2000030499. Registered 1st June 2017, http://www.medresman.org.cn/pub/cn/proj/projectshow.aspx?proj=6333.

摘要

背景

认知障碍是影响日本脑炎（乙脑）患者生活质量的主要后遗症之一。临床治疗主要集中在生命支持方面，缺乏针对性的治疗策略。

方法

进行了一项脑脊液（CSF）蛋白质组学分析研究，纳入了2017年6月至2018年10月期间中国甘肃省的26例乙脑患者以及33例同期住院的排除中枢神经系统（CNS）器质性疾病或CNS感染性疾病的患者。首次对乙脑患者的临床和蛋白质组学数据进行联合分析。

结果

确定了两种预后明显不同的乙脑亚型。与JE1相比，JE2亚型的总生存率较低，认知障碍风险较高。JE2中中性粒细胞（N%）、淋巴细胞（L%）和单核细胞（M%）的百分比显著降低。

结论

乙脑亚组之间蛋白质组格局的差异对认知障碍的预后具有特异性。这些数据还为治疗乙脑所致认知障碍提供了一些潜在的靶蛋白。试验注册：中国临床试验注册中心，ChiCTR2000030499。于2017年6月1日注册，http://www.medresman.org.cn/pub/cn/proj/projectshow.aspx?proj=6333。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/595c4550327f/12974_2022_2439_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/bc46fea655c1/12974_2022_2439_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/c91fd311b35d/12974_2022_2439_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/2db90b62f5f4/12974_2022_2439_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/dd1bd6f5c3a8/12974_2022_2439_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/595c4550327f/12974_2022_2439_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/bc46fea655c1/12974_2022_2439_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/c91fd311b35d/12974_2022_2439_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/3a826d3c70e2/12974_2022_2439_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/2db90b62f5f4/12974_2022_2439_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/dd1bd6f5c3a8/12974_2022_2439_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1ab/8981687/595c4550327f/12974_2022_2439_Fig6_HTML.jpg

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