Lambert-Zechovsky N, Bingen E, Guihaire E, Mancy C, Mercier J C, Beaufils F
Pathol Biol (Paris). 1986 Sep;34(7):855-8.
Morbidity and mortality among children with Pseudomonas aeruginosa infection in Pediatric Intensive Care Unit remains high. Delays in bacterial killing may be responsible for the poor outcome. Antimicrobial sensitivity and timed-killing assays were determined for ticarcillin, azlocillin, piperacillin, cefsulodin, ceftazidime, gentamicin, tobramycin and amikacin alone and in combination against 40 strains of Pseudomonas aeruginosa isolated from blood cultures and tracheal aspirate. Antibiotic concentrations used were at clinically achievable level. None bactericidal effect was observed with each beta-lactamin alone. However with the combinations azlocillin or piperacillin or cefsulodin or ceftazidime plus amikacin a bactericidal effect was observed at 4.5 hours.
儿科重症监护病房中铜绿假单胞菌感染患儿的发病率和死亡率仍然很高。细菌杀灭延迟可能是导致不良预后的原因。对替卡西林、阿洛西林、哌拉西林、头孢磺啶、头孢他啶、庆大霉素、妥布霉素和阿米卡星单独及联合使用针对从血培养和气管吸出物中分离出的40株铜绿假单胞菌进行了抗菌敏感性和定时杀菌试验。所用抗生素浓度为临床可达到的水平。单独使用每种β-内酰胺类药物均未观察到杀菌作用。然而，阿洛西林或哌拉西林或头孢磺啶或头孢他啶与阿米卡星联合使用时，在4.5小时观察到了杀菌作用。
