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可持续大学生活(SUN)研究:一项关于大学生心理健康问题和肌肉骨骼疼痛的可改变风险及预后因素的前瞻性队列研究方案。

Sustainable UNiversity Life (SUN) study: protocol for a prospective cohort study of modifiable risk and prognostic factors for mental health problems and musculoskeletal pain among university students.

作者信息

Edlund Klara, Sundberg Tobias, Johansson Fred, Onell Clara, Rudman Ann, Holm Lena W, Grotle Margreth, Jensen Irene, Côté Pierre, Skillgate Eva

机构信息

Department of Health Promotion Science, Sophiahemmet University, Stockholm, Sweden

Unit of Intervention Research on Worker Health, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.

出版信息

BMJ Open. 2022 Apr 4;12(4):e056489. doi: 10.1136/bmjopen-2021-056489.

DOI:10.1136/bmjopen-2021-056489
PMID:35379630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8980731/
Abstract

INTRODUCTION

Mental health problems and musculoskeletal pain are common health problems among young adults including students. Little is known about the aetiology and prognosis of these problems in university students. We aim to determine the role of personal, sociodemographic, academic and environmental factors for risk and prognosis of symptoms of depression, anxiety and stress as well as musculoskeletal pain in university students. The constructs that will be studied are based on the biopsychosocial model and psychopathology associated with disabling pain. This model acknowledges illness to consist of interrelated mechanisms categorised into biological, psychological, environmental and social cues.

METHODS AND ANALYSIS

This cohort study aims to recruit around 5000 Swedish full-time students. Data will be collected using five online surveys during one academic year. A subgroup (n=1851) of the cohort, recruited before the COVID-19 pandemic, receive weekly text messages with three short questions assessing mood, worry and pain, sent through the web-based platform SMS-track . Statistical analyses will include Kaplan-Meier estimates, Cox regression analyses, multinomial logistic regression analyses and generalised estimating equations. We will assess effect measure modification when relevant and conduct sensitivity analyses to assess the impact of lost to follow-up.

PROTOCOL AMENDMENTS

Due to opportunity and timing of the study, with relevance to the outbreak of the COVID-19 pandemic, this study further aims to address mental health problems, musculoskeletal pain and lifestyle in university students before and during the pandemic.

ETHICS AND DISSEMINATION

The Sustainable UNiversity Life study was approved by the Swedish ethics authority (2019-03276; 2020-01449). Results will be disseminated through peer-reviewed research papers, reports, research conferences, student theses and stakeholder communications.

TRIAL REGISTRATION NUMBER

NCT04465435.

摘要

引言

心理健康问题和肌肉骨骼疼痛是包括学生在内的年轻人中常见的健康问题。对于大学生中这些问题的病因和预后知之甚少。我们旨在确定个人、社会人口学、学术和环境因素对大学生抑郁、焦虑和压力症状以及肌肉骨骼疼痛的风险和预后的作用。将要研究的结构基于生物心理社会模型和与致残性疼痛相关的精神病理学。该模型承认疾病由相互关联的机制组成,这些机制分为生物、心理、环境和社会线索。

方法与分析

这项队列研究旨在招募约5000名瑞典全日制学生。在一个学年内通过五次在线调查收集数据。该队列的一个亚组(n = 1851)在新冠疫情大流行之前招募,通过基于网络的平台SMS-track接收每周包含三个简短问题的短信,这些问题用于评估情绪、担忧和疼痛。统计分析将包括Kaplan-Meier估计、Cox回归分析、多项逻辑回归分析和广义估计方程。我们将在相关时评估效应测量修正,并进行敏感性分析以评估失访的影响。

方案修正

由于研究的时机和机会,与新冠疫情大流行的爆发相关,本研究进一步旨在解决大学生在疫情之前和期间的心理健康问题、肌肉骨骼疼痛和生活方式。

伦理与传播

“可持续大学生活”研究获得了瑞典伦理委员会的批准(2019 - 03276;2020 - 01449)。研究结果将通过同行评审的研究论文、报告、研究会议、学生论文和与利益相关者的沟通进行传播。

试验注册号

NCT04465435。

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