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金表面淀粉样β肽自组装聚集体的见解

Insights from Self-Assembled Aggregates of Amyloid β Peptides on Gold Surfaces.

作者信息

Dey Chinmay, Roy Madhuparna, Dey Somdatta Ghosh

机构信息

School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India.

出版信息

ACS Omega. 2022 Mar 15;7(12):9973-9983. doi: 10.1021/acsomega.1c06056. eCollection 2022 Mar 29.

DOI:10.1021/acsomega.1c06056
PMID:35382274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8973063/
Abstract

Amyloid β (Aβ) peptides mutated at different positions using a cysteine moiety assemble on Au electrodes using the thiol functionality of cysteine. Self-assembled monolayers (SAMs) of Aβ on Au surfaces can act as abiological platforms that allow the mimicking of fibrils and oligomeric Aβ via the formation of controlled large and small peptide aggregates. These Aβ constructs bind with heme and Cu and exhibit different reactivities. These abiological platforms can also be used to investigate potential drugs that can interact with heme and Cu-Aβ. SAM formation of Aβ mutants allows the study of different morphology and structure as well as behavior changes on binding with different metals and cytochrome (Cyt ). This review provides a detailed insight into the structure and reactivities of various Aβ aggregated on Au electrodes mimicking the cell membrane.

摘要

使用半胱氨酸部分在不同位置发生突变的淀粉样β（Aβ）肽利用半胱氨酸的硫醇官能团在金电极上组装。金表面上Aβ的自组装单分子层（SAMs）可作为非生物平台，通过形成可控的大、小肽聚集体来模拟原纤维和寡聚Aβ。这些Aβ构建体与血红素和铜结合并表现出不同的反应性。这些非生物平台还可用于研究能够与血红素和铜 - Aβ相互作用的潜在药物。Aβ突变体的SAM形成允许研究不同的形态和结构以及与不同金属和细胞色素（Cyt）结合时的行为变化。本综述详细深入地探讨了在模仿细胞膜的金电极上聚集的各种Aβ的结构和反应性。

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Metal Binding to Aβ Peptides Inhibits Interaction with Cytochrome : Insights from Abiological Constructs.金属与β-淀粉样肽结合抑制其与细胞色素的相互作用：来自非生物构建体的见解
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Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release.
β-淀粉样寡聚体激活凋亡性BAK孔道以释放细胞色素c。
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Dalton Trans. 2014 Sep 21;43(35):13377-83. doi: 10.1039/c4dt01991a.
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Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease.细胞色素 c 与与阿尔茨海默病相关的血红素 Aβ之间的直接电子转移。
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