Pathology Unit, Department of Medical Sciences, University of Turin, Via Santena 7, 10126, Torino, Italy.
General Surgery 2U, Department of Surgical Sciences, AOU Città Della Salute e Della Scienza di Torino, Turin, Italy.
BMC Surg. 2022 Apr 6;22(1):128. doi: 10.1186/s12893-022-01554-7.
Gallbladder hemangioma is an exceptionally rare entity, with only ten cases reported in literature hitherto. The here described case is the first report of a gallbladder hemangioma coexisting with gallstones.
A 76-year-old male was hospitalized following repeated episodes of epigastric pain. Patient's medical history included primary hypertension, type 2 diabetes mellitus, dyslipidemia, obesity and hyperuricemia. Physical examination revealed marked pain in the right hypochondriac region, and laboratory workup was notable for mildly elevated glycemia (125 mg/dL) and pancreatic amylase (60 IU/L). Abdominal ultrasound showed multiple gallstones, a thickened gallbladder wall and mild edema of the perivisceral adipose tissue as well as a hepatic angioma. During surgery, an incidental subserosal nodule of about 1 cm was detected within the gallbladder fundus. After surgery, the clinical course was uneventful and the patient was discharged. Histopathological examination of the subserosal nodule showed multiple dilated vascular channels within a sclerosing matrix, a finding consistent with a cavernous hemangioma. Diffuse chronic cholecystitis was also present.
Gallbladder hemangiomas represent a rare, likely underdiagnosed condition which can be undetected during the preoperative workup.
胆囊血管瘤是一种非常罕见的疾病，迄今为止文献中仅报道了十例。本文描述的病例是首例胆囊血管瘤合并胆囊结石的病例。
一名 76 岁男性因反复上腹痛住院。患者既往有原发性高血压、2 型糖尿病、血脂异常、肥胖和高尿酸血症。体格检查显示右上腹明显疼痛，实验室检查显示轻度高血糖（125mg/dL）和胰腺淀粉酶（60IU/L）升高。腹部超声显示多发胆囊结石、胆囊壁增厚和周围脂肪组织轻度水肿，以及肝血管瘤。手术中发现胆囊底部有一个约 1cm 的浆膜下小结节。术后患者临床过程平稳，出院。浆膜下结节的组织病理学检查显示硬化基质内有多个扩张的血管通道，符合海绵状血管瘤的表现。还存在弥漫性慢性胆囊炎。
胆囊血管瘤是一种罕见的、可能被漏诊的疾病，在术前检查中可能无法发现。
