Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China.
Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Br J Ophthalmol. 2023 Aug;107(8):1156-1164. doi: 10.1136/bjophthalmol-2021-320618. Epub 2022 Apr 5.
To examine the normative profile of retinal nerve fibre layer (RNFL) thickness and ocular parameters based on spectral-domain optical coherence tomography (SD-OCT) and its associations with related parameters among the Chinese population.
This population-based cohort Handan Eye Study (HES) recruited participants aged≥30 years. All subjects underwent a standardised ophthalmic examination. Peripapillary RNFL thickness was obtained using SD-OCT. Mixed linear models were adopted to evaluate the correlation of RNFL thickness with ocular parameters as well as systemic factors. R V.3.6.1 software was used for statistical analysis.
3509 subjects (7024 eyes) with the average age of 55.54±10.37 were collected in this analysis. Overall mean RNFL thickness measured was 113.46±10.90 µm, and the thickest quadrant of parapapillary RNFL was the inferior quadrant, followed by the superior quadrant, the nasal quadrant and the temporal quadrant. In the multivariate linear regression model, thinner RNFL thickness was remarkable association with male (p<0.001), older age (p<0.001), increased body mass index (>30, p=0.018), absence of diabetes (p=0.009), history of cataract surgery (p=0.001), higher intraocular pressure (p=0.007), lower spherical equivalent (p<0.001) and increased axial length (p=0.048).
In non-glaucoma individuals, this difference of RNFL thickness in Chinese population should be noted in making disease diagnoses. Meanwhile, multiple ocular and systemic factors are closely related to the thickness of RNFL. Our findings further emphasise the need to demonstrate ethnic differences in RNFL thickness and the specificity of associated ocular and systemic factors, as well as to develop better normative databases worldwide.
HES was registered in Chinese Clinical Trial Registry website, and the registry number was ChiCTR-EOC-17013214.
基于频域光相干断层扫描（SD-OCT），研究中国人视网膜神经纤维层（RNFL）厚度的正常谱以及眼部参数，并探讨其与相关参数的关系。
这项基于人群的邯郸眼病研究（HES）招募了年龄≥30 岁的参与者。所有受试者均接受了标准眼科检查。使用 SD-OCT 获得视盘周围 RNFL 厚度。采用混合线性模型评估 RNFL 厚度与眼部参数以及全身因素的相关性。使用 R V.3.6.1 软件进行统计分析。
本分析共纳入 3509 名受试者（7024 只眼），平均年龄为 55.54±10.37 岁。总体平均 RNFL 厚度为 113.46±10.90 µm，视盘周围 RNFL 最厚的象限是下方象限，其次是上方象限、鼻侧象限和颞侧象限。在多元线性回归模型中，较薄的 RNFL 厚度与男性（p<0.001）、年龄较大（p<0.001）、体重指数增加（>30，p=0.018）、无糖尿病（p=0.009）、白内障手术史（p=0.001）、较高的眼压（p=0.007）、较低的等效球镜（p<0.001）和较长的眼轴（p=0.048）显著相关。
在非青光眼个体中，中国人群 RNFL 厚度的这种差异在做出疾病诊断时应予以注意。同时，多种眼部和全身因素与 RNFL 厚度密切相关。我们的研究结果进一步强调，需要证明 RNFL 厚度的种族差异以及相关眼部和全身因素的特异性，并在全球范围内建立更好的正常参考数据库。
HES 在中华临床试验注册中心网站注册，注册号为 ChiCTR-EOC-17013214。
