Al-Sa'ad Mouna M, Shatarat Amjad T, Amarin Justin Z, Badran Darwish H
Department of Special Surgery, School of Medicine, The University of Jordan, Queen Rania Al-Abdullah Street, Amman 11942, Jordan.
Department of Anatomy and Histology, School of Medicine, The University of Jordan, Queen Rania Al-Abdullah Street, Amman 11942, Jordan.
J Ophthalmol. 2018 Sep 17;2018:7238464. doi: 10.1155/2018/7238464. eCollection 2018.
Peripapillary retinal nerve fiber layer (pRNFL) thickness is subject to high variability. Normative values of pRNFL thickness remain undocumented in the Middle East. The aim of our study is to assess the normative values of pRNFL thickness in a Middle Eastern population.
A retrospective chart review of 74 patients was conducted. Outpatients who had presented to the ophthalmology clinic at the Jordan University Hospital between January 2016 and July 2018 were consecutively sampled. Measurements had been recorded using Fourier-domain optical coherence tomography. Multivariable regression models were developed to generate predicted normative values with adjustments to candidate confounders.
The mean global pRNFL thickness was 99 ± 11 m. The mean quadrantic pRNFL thickness increased from the nasal quadrant (75 ± 16 m) to the temporal (82 ± 20 m), superior (114 ± 20 m), and inferior (125 ± 20 m) quadrants. Gender and eye sidedness did not contribute to the variability in pRNFL thickness. The relationship between aging and pRNFL thinning is independent of diabetes mellitus type 2 and systemic hypertension. Both systemic conditions significantly predicted pRNFL changes despite negative fundoscopic findings.
Our set of predicted normative data may be used to interpret measurements of pRNFL thickness in Middle Eastern patients. Our findings suggest that systemic conditions with potential ocular manifestations may require consideration in predictive models of pRNFL thickness, even in the absence of gross fundoscopic findings. Normative data from additional Middle Eastern populations are required to appraise our models, which adjust for common clinical confounders.
视乳头周围视网膜神经纤维层（pRNFL）厚度存在高度变异性。中东地区尚未有pRNFL厚度的正常参考值记录。本研究旨在评估中东人群中pRNFL厚度的正常参考值。
对74例患者进行回顾性病历审查。连续抽取2016年1月至2018年7月期间在约旦大学医院眼科门诊就诊的门诊患者。使用傅里叶域光学相干断层扫描记录测量值。建立多变量回归模型以生成经候选混杂因素调整后的预测正常参考值。
全球pRNFL平均厚度为99±11μm。象限性pRNFL平均厚度从鼻侧象限（75±16μm）向颞侧（82±20μm）、上方（114±20μm）和下方（125±20μm）象限递增。性别和眼别对pRNFL厚度的变异性无影响。衰老与pRNFL变薄之间的关系独立于2型糖尿病和系统性高血压。尽管眼底镜检查结果为阴性，但这两种全身性疾病均显著预测了pRNFL的变化。
我们的一组预测正常参考数据可用于解释中东患者pRNFL厚度的测量结果。我们的研究结果表明，即使在眼底镜检查无明显异常的情况下，在pRNFL厚度预测模型中也可能需要考虑具有潜在眼部表现的全身性疾病。需要更多中东人群的正常参考数据来评估我们针对常见临床混杂因素进行调整的模型。
