Hong Yiyi, Lan Lin, Hu Xiangyu, Zuo Yuan, Deng Meiqiu, Ye Kun, Xu Fan, Chen Changzheng, Li Min
Eye Center of Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, Hubei, China.
Research Center of Ophthalmology, Guangxi Academy of Medical Sciences and Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology and Department of Ophthalmology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China.
Sci Rep. 2024 Aug 1;14(1):17824. doi: 10.1038/s41598-024-68589-z.
This study aimed to investigate the relationship between hemodialysis duration (HDD) and retinal nerve fiber layer (RNFL) thickness. A total of 60 patients receiving maintenance hemodialysis and 67 healthy controls were analyzed. Spectral domain optical coherence tomography (SD-OCT) was employed to measure annular RNFL thicknesses. The hemodialysis group exhibited reduced temporal and inferior RNFL thicknesses relative to the control group. In hemodialysis patients, the inferior RNFL thickness was negatively correlated with HDD and positively correlated with intraocular pressure (IOP). Moreover, IOP was positively correlated with HDD. Mediation analysis showed that the negative correlation between HDD and inferior RNFL thickness was mediated by IOP. In conclusion, hemodialysis leads to temporal and inferior RNFL thinning, and the thickness reduction is proportional to hemodialysis duration. However, such changes are not induced by an increase in IOP.
本研究旨在探讨血液透析时长（HDD）与视网膜神经纤维层（RNFL）厚度之间的关系。共分析了60例接受维持性血液透析的患者和67名健康对照者。采用频域光学相干断层扫描（SD-OCT）测量环形RNFL厚度。与对照组相比，血液透析组颞侧和下方RNFL厚度降低。在血液透析患者中，下方RNFL厚度与HDD呈负相关，与眼压（IOP）呈正相关。此外，IOP与HDD呈正相关。中介分析表明，HDD与下方RNFL厚度之间的负相关是由IOP介导的。总之，血液透析导致颞侧和下方RNFL变薄，厚度降低与血液透析时长成正比。然而，这种变化并非由IOP升高引起。
