Reikerås O, Gunnes P
Scand J Clin Lab Invest. 1986 Nov;46(7):671-5. doi: 10.3109/00365518609083730.
The effects of acute ischaemic heart failure on renal blood flow and the influence of dopamine at low dose range and high doses of insulin were examined. Acute left ventricular (LV) failure was induced in dogs by injection of 50-micron plastic microspheres into the left main coronary artery. The dogs showed signs of severely depressed LV function. Cardiac output was decreased to a significantly greater extent than renal blood flow, and while total peripheral resistance was significantly increased, there were no significant changes in renal vascular resistance. The results indicate different sympathetic discharge to the various vascular beds during acute ischaemic heart failure. Dopamine at low dose range and high doses of insulin were found to improve myocardial contractility and to reduce renal vascular resistance and increase renal blood flow.
研究了急性缺血性心力衰竭对肾血流量的影响以及低剂量多巴胺和高剂量胰岛素的作用。通过向犬左冠状动脉主干注射50微米的塑料微球诱导急性左心室（LV）衰竭。犬表现出左心室功能严重抑制的迹象。心输出量的降低幅度明显大于肾血流量，虽然总外周阻力显著增加，但肾血管阻力无明显变化。结果表明，急性缺血性心力衰竭期间对不同血管床的交感神经放电不同。发现低剂量多巴胺和高剂量胰岛素可改善心肌收缩力，降低肾血管阻力并增加肾血流量。
