Biomedical Program, University of Wyoming, Laramie, Wyoming, USA.
Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington, USA.
Obesity (Silver Spring). 2022 May;30(5):994-998. doi: 10.1002/oby.23418. Epub 2022 Apr 6.
Food-seeking behaviors can be driven by food-associated cues, and palatable food seeking in response to food cues is a risk factor for obesity development. Cue-induced food seeking increases following a period of abstinence, a behavioral phenomenon known as "incubation of craving," which may contribute to an individual's difficulty abstaining from palatable foods. Pharmacological and environmental manipulations have been employed to try and reduce incubation of craving, albeit primarily in drug abuse paradigms. The goal of this study was to determine whether forced exercise can attenuate incubation of high-fat food craving.
Male Sprague Dawley rats learned to self-administer high-fat pellets (60%) in combination with a compound cue (light + tone). The influence of high-intensity interval exercise on the time-dependent increase in cue-induced lever responding was investigated 30 days after the first cue test.
Rats exposed to exercise during abstinence did not express incubation of craving.
The results suggest that high-intensity exercise can prevent the establishment of incubation of craving for foods high in fat and may reduce cue-induced maladaptive food-seeking behaviors that contribute to overeating and obesity.
食物寻求行为可能受到食物相关线索的驱动，而对食物线索的美味食物寻求是肥胖发展的一个风险因素。在禁欲期后，线索诱导的食物寻求会增加，这是一种被称为“渴望孵化”的行为现象，这可能导致个体难以戒除美味食物。已经采用药理学和环境操作来试图减少渴望孵化，尽管主要是在药物滥用范式中。本研究的目的是确定强制运动是否可以减轻高脂肪食物渴望的孵化。
雄性 Sprague Dawley 大鼠学会了在复合线索（光+音）的组合下自行摄取高脂肪丸（60%）。在第一次线索测试 30 天后，研究了高强度间歇运动对线索诱导的杠杆反应随时间增加的影响。
在禁欲期间接受运动的大鼠没有表现出渴望孵化。
结果表明，高强度运动可以防止高脂肪食物渴望的孵化，并且可能减少导致暴饮暴食和肥胖的线索诱导的适应性不良的食物寻求行为。
