Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC8, Tampa, FL, 33612, USA.
Transl Stroke Res. 2022 Dec;13(6):863-865. doi: 10.1007/s12975-022-01018-3. Epub 2022 Apr 6.
Pericytes are a heterogenous population that plays multiple important roles in both physiological and pathological conditions. Although many markers and transgenic mouse lines have been used to identify pericytes, these tools all have limitations. For example, many of them are not pericyte-specific and none of them are able to distinguish different subtypes of pericyte. Here, we summarize commonly used pericyte markers and transgenic mouse lines, compare their unique features and limitations, and discuss key points to consider when using these tools or interpreting data generated by using them. Identifying/developing pericyte-specific and subtype-specific markers/tools will fill the gap of knowledge and substantially move the field forward.
周细胞是一个异质性群体，在生理和病理条件下发挥多种重要作用。虽然已经使用了许多标记物和转基因小鼠品系来鉴定周细胞，但这些工具都存在局限性。例如，许多标记物都不是周细胞特异性的，也没有一种能够区分不同亚型的周细胞。在这里，我们总结了常用的周细胞标记物和转基因小鼠品系，比较了它们的独特特征和局限性，并讨论了使用这些工具或解释使用这些工具生成的数据时需要考虑的要点。鉴定/开发周细胞特异性和亚型特异性的标记物/工具将填补知识空白，并极大地推动该领域的发展。
