在青光眼和非青光眼眼中，光学相干断层扫描血管造影的黄斑血管参数的日内重复性和日间可重复性。

Intrasession Repeatability and Intersession Reproducibility of Macular Vessel Parameters on Optical Coherence Tomography Angiography in Glaucomatous and Non-Glaucomatous Eyes.

机构信息

USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, CA, USA.

Department of Bioengineering, University of Washington, Seattle, WA, USA.

出版信息

Curr Eye Res. 2022 Jul;47(7):1068-1076. doi: 10.1080/02713683.2022.2061004. Epub 2022 Apr 11.

DOI:10.1080/02713683.2022.2061004

PMID:35385336

Abstract

PURPOSE

Using optical coherence tomography angiography (OCTA), this study compared intrasession repeatability versus intersession reproducibility of macular vessel parameters in glaucoma and non-glaucoma subjects.

METHODS

6 × 6 mm macular OCTA scans (Cirrus HD-OCT 5000) were acquired from glaucomatous and non-glaucomatous subjects as part of an observational, longitudinal study. Vessel area density (VAD) and vessel skeleton density (VSD) were calculated using research-based quantification software while perfusion density (PD) and vessel density (VD) were calculated using commercially developed software (Cirrus 11.0, Carl Zeiss Meditec). Intrasession repeatability and intersession reproducibility were determined using within-eye standard deviation (S), within-eye coefficient of repeatability (CR), within-eye coefficient of variation (CV), and intraclass correlation coefficients (ICC).

RESULTS

The intrasession repeatability and intersession reproducibility for macular OCTA parameters were similar to one another for both non-glaucomatous and glaucomatous eyes. Intrasession CV from the non-glaucoma group ( = 73) was 1.097% for VAD, 1.007% for VSD, 2.980% for PD, and 2.714% for VDZ. Intersession CV from the non-glaucoma group ( = 55) was 1.389% for VAD, 1.279% for VSD, 2.935% for PD, and 2.695% for VD. Intrasession CV from the glaucoma group ( = 59) was 1.189% for VAD, 0.970% for VSD, 3.827% for PD, and 3.542% for VD. Intersession CV from the glaucoma group ( = 45) was 1.412% for VAD, 1.132% for VSD, 3.915% for PD, and 3.654% for VD. Non-glaucomatous intrasession ICC ranged from 0.711 to 0.824, non-glaucomatous intersession ICC ranged from 0.649 to 0.762, glaucomatous intrasession ICC ranged from 0.710 to 0.853, and glaucomatous intersession ICC ranged from 0.661 to 0.827.

CONCLUSIONS

Macular OCTA scans can be a useful tool in monitoring the longitudinal progression of glaucoma due to their high repeatability and reproducibility.

摘要

目的

本研究采用光学相干断层扫描血管造影术（OCTA）比较了青光眼和非青光眼患者黄斑血管参数的同次内重复性与不同次间可重复性。

方法

作为一项观察性纵向研究的一部分，对青光眼和非青光眼患者进行了 6×6mm 黄斑 OCTA 扫描（Cirrus HD-OCT 5000）。使用基于研究的量化软件计算血管面积密度（VAD）和血管骨架密度（VSD），使用商业开发的软件（Cirrus 11.0，卡尔蔡司医疗技术公司）计算灌注密度（PD）和血管密度（VD）。使用眼内标准差（S）、眼内可重复性系数（CR）、眼内变异系数（CV）和组内相关系数（ICC）来确定同次内重复性和不同次间可重复性。

结果

对于非青光眼和青光眼眼，黄斑 OCTA 参数的同次内重复性和不同次间可重复性彼此相似。非青光眼组的同次内 CV（n=55）分别为 VAD1.097%、VSD1.007%、PD2.980%和 VDZ2.714%。非青光眼组的不同次间 CV（n=55）分别为 VAD1.389%、VSD1.279%、PD2.935%和 VD2.695%。青光眼组的同次内 CV（n=59）分别为 VAD1.189%、VSD0.970%、PD3.827%和 VD3.542%。青光眼组的不同次间 CV（n=45）分别为 VAD1.412%、VSD1.132%、PD3.915%和 VD3.654%。非青光眼组的同次内 ICC 范围为 0.711 至 0.824，非青光眼组的不同次间 ICC 范围为 0.649 至 0.762，青光眼组的同次内 ICC 范围为 0.710 至 0.853，青光眼组的不同次间 ICC 范围为 0.661 至 0.827。