酮体调节血管内皮稳态。
Ketones regulate endothelial homeostasis.
机构信息
Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Robarts Research Institute, University of Western Ontario, London, ON, Canada.
出版信息
Cell Metab. 2022 Apr 5;34(4):513-515. doi: 10.1016/j.cmet.2022.03.008.
In a recent paper in EMBO Molecular Medicine, Weis et al. reveal that cardiac endothelial cells can oxidize ketone bodies, which enhances cell proliferation, migration, and vessel sprouting. Furthermore, increasing ketone body levels with a ketogenic diet can increase endothelial cell proliferation and prevent blood vessel rarefication in hypertrophied mouse hearts. This suggests that increasing endothelial cell ketone oxidation has potential in treating heart failure.
在最近发表在《EMBO 分子医学》上的一篇论文中，Weis 等人揭示了心脏内皮细胞可以氧化酮体，这增强了细胞的增殖、迁移和血管生成。此外，通过生酮饮食增加酮体水平可以增加内皮细胞的增殖，并防止肥厚小鼠心脏中的血管稀疏化。这表明增加内皮细胞的酮体氧化在治疗心力衰竭方面具有潜力。
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