School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
Pediatr Dermatol. 2021 Nov;38(6):1575-1576. doi: 10.1111/pde.14849. Epub 2021 Oct 29.
Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by urticarial plaques and/or vesicles and tense bullae. A unique presentation of BP can occur during pregnancy, the postpartum period after delivery, or with the initiation of contraception, in which case it is referred to as pemphigoid gestationis (PG). In rare instances, newborns born to mothers with PG may also present with blisters due to transplacental passage of maternal anti-bullous pemphigoid 180 (BP180) or 230 (BP230) immunoglobulin G (IgG). In this report, we present an unusual case of neonatal PG in an infant born to an asymptomatic mother without a previous diagnosis of PG.
大疱性类天疱疮（BP）是一种自身免疫性水疱性疾病，其特征为荨麻疹样斑块和/或水疱和紧张性大疱。BP 的一种独特表现可发生在妊娠期间、分娩后的产后期或开始避孕时，此时称为妊娠性大疱性类天疱疮（PG）。在罕见情况下，由于母亲抗大疱性类天疱疮 180（BP180）或 230（BP230）免疫球蛋白 G（IgG）经胎盘传递，患有 PG 的母亲所生的新生儿也可能出现水疱。本报告介绍了一例不常见的新生儿 PG 病例，患儿出生于无症状母亲，且母亲此前未被诊断为 PG。
