tau蛋白沉积在唐氏综合征早期认知衰退中的作用。
Role of tau deposition in early cognitive decline in Down syndrome.
作者信息
Hartley Sigan L, Handen Benjamin L, Tudorascu Dana, Lee Laise, Cohen Annie, Piro-Gambetti Brianna, Zammit Matthew, Klunk William, Laymon Charles, Zaman Shahid, Ances Beau M, Sabbagh Marwan, Christian Bradley T
机构信息
Waisman Center University of Wisconsin-Madison Madison Wisconsin USA.
School of Human Ecology University of Wisconsin-Madison Madison Wisconsin USA.
出版信息
Alzheimers Dement (Amst). 2022 Apr 1;14(1):e12256. doi: 10.1002/dad2.12256. eCollection 2022.
INTRODUCTION
Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [F]AV-1451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (Aβ) PET in Down syndrome (DS).
METHODS
Data from 123 non-demented adults with DS ( = 47 years, standard deviation = 6.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [T] vs. low tau [T]) variable. Global PET Aβ SUVR was assessed as binary variable (Aβ- vs. Aβ+).
RESULTS
In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the Aβ+ but not Aβ- group. The Aβ+/T group evidenced significantly worse episodic memory than the Aβ+/T group.
DISCUSSION
Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.
引言
基于淀粉样蛋白/ tau蛋白/神经退行性变（AT[N]）模型，本研究探讨了tau正电子发射断层扫描（PET）生物标志物[F]AV-1451是否与唐氏综合征（DS）中超出淀粉样β蛋白（Aβ）PET预测范围的情景记忆问题相关。
方法
分析了123名非痴呆的DS成年人（年龄=47岁，标准差=6.34）的数据。线索回忆测试评估情景记忆。tau PET标准化摄取值比率（SUVR）在Braak区域作为连续变量和二元变量（高tau [T]与低tau [T]）进行评估。整体PET Aβ SUVR作为二元变量（Aβ-与Aβ+）进行评估。
结果
在对对照进行调整的模型中，tau SUVR在Aβ+组而非Aβ-组中与情景记忆表现呈负相关。Aβ+/T组的情景记忆明显比Aβ+/T组差。
讨论
与晚发性和常染色体显性阿尔茨海默病（AD）相似，高tau是DS中早期前驱AD的一个指标。
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