Cui Guoqiang, Yang Yun, Yin Fang-Fang, Yoo David, Kim Grace, Duan Jun
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 USA.
J Radiosurg SBRT. 2022;8(1):47-54.
Two automated treatment planning techniques were evaluated for multiple brain metastases using a single isocenter. One technique is knowledge-based planning (KBP) using a stereotactic radiosurgery (SRS) model in Eclipse treatment planning system (TPS); and the other is the Multiple Brain Mets (MBM) SRS technique in Brainlab Elements TPS. Eighteen plans each with 3-10 lesions were used for the study. Plan evaluation metrics included the planning target volume (PTV) coverage, conformity index (CI), total monitor units (MUs), plan optimization time, brain V, V, and V. Both the KBP and MBM planning techniques produced comparable plans to the manually generated clinical plans in terms of PTV coverage and CI. For irregularly shaped lesions, the KBP plans provided more conformal dose distribution to the PTV than the MBM plans. The KBP plans took significantly longer time to plan but have fewer MUs than the MBM plans. The MBM plans spared normal brain tissues better than the KBP plans in terms of V.
使用单个等中心对两种用于多发性脑转移瘤的自动治疗计划技术进行了评估。一种技术是在Eclipse治疗计划系统（TPS）中使用立体定向放射外科（SRS）模型的基于知识的计划（KBP）；另一种是Brainlab Elements TPS中的多脑转移瘤（MBM）SRS技术。本研究使用了18个计划，每个计划有3至10个病灶。计划评估指标包括计划靶体积（PTV）覆盖率、适形指数（CI）、总监测单位（MU）、计划优化时间、脑V、V和V。KBP和MBM计划技术在PTV覆盖率和CI方面产生的计划与手动生成的临床计划相当。对于形状不规则的病灶，KBP计划比MBM计划为PTV提供了更适形的剂量分布。KBP计划的规划时间明显更长，但MU比MBM计划更少。在V方面，MBM计划比KBP计划更好地保护了正常脑组织。
